Digital Ischemia Due to Essential Thrombocythemia: A Case Report

Papadonikolakis, Anastasios; Chloros, George D.; Smith, Beth Paterson; Koman, L. Andrew

doi:10.1016/j.jhsa.2007.05.010

Cited by 10 publications

(7 citation statements)

References 23 publications

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“…Itching was the most common symptom reported; however, it was reported at very different percentages, ranging from 3% to 46%, depending on the study 21,27 (Gugliotta L, for the RIT; personal communication). 19 Papadonikolakis et al 37 Bakst et al 38…”

Section: Resultsmentioning

confidence: 99%

“…36 In patients with ET, Raynaud's phenomenon is rare. It has been described in a few individual case reports 34,37 and in < 1% of the patients in the study by Itin and Winkelmann. 19 To prevent or treat this manifestation, patients should avoid cold temperatures and wear gloves and thermal underwear; vasodilating agents can also be useful.…”

Section: Livedo Reticularismentioning

confidence: 87%

“…The dosage is 3 capsules daily for 1 week and then 2 capsules daily until symptom improvement. 37 For more severe forms, characterized by frequent and intense attacks, treatment with oral calcium channel blockers can be considered. Of these drugs, nifedipine (10-30 mg, 3 times daily) and diltiazem (30-90 mg, 3 times daily) have been used the most.…”

Section: Livedo Reticularismentioning

confidence: 99%

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Essential Thrombocythemia: The Dermatologic Point of View

Cozzani

Iurlo

Merlo

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

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Section: Resultsmentioning

confidence: 99%

Section: Livedo Reticularismentioning

confidence: 87%

Section: Livedo Reticularismentioning

confidence: 99%

See 1 more Smart Citation

Essential Thrombocythemia: The Dermatologic Point of View

Cozzani

Iurlo

Merlo

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

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“…[136,137] A history of tobacco use in a young man with acute onset of cyanotic or ischemic digits warrants further work-up for thromboangiitis obliterans (Buerger disease). [153][154][155] However, such findings are non-specific and other heritable and acquired hypercoagulable states including antiphospholipid antibodies (figure 10) must be sought via prudent laboratory analysis. [139] Prostitutes or those with risk factors for sexually The Purple Digit transmitted diseases may present with purple digits as the sole manifestation of secondary syphilis.…”

Section: Peripheral Pulses Normalmentioning

confidence: 99%

The Purple Digit

Brown

Zirwas

English

2010

American Journal of Clinical Dermatology

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The acute onset of purple digits is a concerning manifestation and may represent underlying, potentially life-threatening disease. Correctly identifying the etiology of purple digits is essential to proper management, and can aid in the diagnosis of systemic disease. Multiple causes of purple digits and significant overlap in clinical presentation can make diagnosis difficult. Despite the various causes of acute purple digits in the published literature, an algorithmic approach to the evaluation and management of the most common and alarming etiologies has yet to be established. The initial step in evaluating a patient with purple digits is to determine if the cause is associated with hypoxemia or trauma. If the patient is in a stable condition, the dermatologist needs to determine if the process could be related to cold exposure such as Raynaud phenomenon, acrocyanosis, pernio, cryoglobulinemia or frostbite. If the disease occurs independent of temperature, physical examination and histological evaluation of the skin is recommended. The lack of peripheral pulses are concerning for acute arterial thrombosis from peripheral vascular disease or arterial embolism. Non-blanching skin changes on the digit that lack inflammation and microthrombosis most likely represent a bleeding or platelet abnormality; however, if microthrombi are identified a more life-threatening processes such as purpura fulminans or embolic phenomenon may be occurring. Evidence of blood vessel inflammation suggests a leukocytoclastic vasculitis. The patient with a purple blanching digit and normal pulses requires an extensive historical review to help determine the cause. This review presents an algorithmic approach to assist in the evaluation and management of the purple digit.

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“…1 Systemic conditions such as collagen vascular diseases, myeloproliferative disorders, and medications, including oral contraceptives, estrogenic hormones, raloxifene, chemotherapeutic agents, and erythropoiesis-stimulating agents, can predispose to arterial thrombosis. 2,3 The use of tamoxifen has been reported to be associated with thrombosis of the tibial artery. 4 To our knowledge, no reports were published of digital artery thrombosis following the use of tamoxifen.…”

mentioning

confidence: 99%

Thrombosis of Digital Arteries Associated with Tamoxifen Use: Case Report

Hutchison

Rayan

2011

J reconstr Microsurg

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Arterial thrombosis in the upper extremity occurs often at the wrist. We report a unique case of thrombosis that involved multiple digital arteries, without radial or ulnar artery involvement, which developed only after using tamoxifen despite chronic occupational blunt percussive hand use. Revascularization was achieved after thrombectomy. Multiple digital arterial thromboses may complicate the use of tamoxifen.

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Digital Ischemia Due to Essential Thrombocythemia: A Case Report

Cited by 10 publications

References 23 publications

Essential Thrombocythemia: The Dermatologic Point of View

Essential Thrombocythemia: The Dermatologic Point of View

The Purple Digit

Thrombosis of Digital Arteries Associated with Tamoxifen Use: Case Report

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