Digital Light Processing Based Three-dimensional Printing for Medical Applications

Zhang, Jiumeng; Hu, Q.; Wang, Shuai; Tao, Jie; Gou, Maling

doi:10.18063/ijb.v6i1.242

Cited by 235 publications

(145 citation statements)

References 73 publications

(110 reference statements)

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“…This has led to its widespread availability to private consumers and research institutions. In this technique, the printed objects are built from a resin in a layer-by-layer configuration by controlled UV photopolymerization, thus providing a simple alternative to conventional fabrication methods [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Microfluidic Devices for Drug Release Assays

et al. 2020

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Microfluidics research for various applications, including drug delivery, cell-based assays and biomedical research has grown exponentially. Despite this technology’s enormous potential, drawbacks include the need for multistep fabrication, typically with lithography. We present a one-step fabrication process of a microfluidic chip for drug dissolution assays based on a 3D printing technology. Doxorubicin porous and non-porous microspheres, with a mean diameter of 250µm, were fabricated using a conventional “batch” or microfluidic method, based on an optimized solid-in-oil-in-water protocol. Microspheres fabricated with microfluidics system exhibited higher encapsulation efficiency and drug content as compared with batch formulations. We determined drug release profiles of microspheres in varying pH conditions using two distinct dissolution devices that differed in their mechanical barrier structures. The release profile of the “V” shape barrier was similar to that of the dialysis sac test and differed from the “basket” barrier design. Importantly, a cytotoxicity test confirmed biocompatibility of the printed resin. Finally, the chip exhibited high durability and stability, enabling multiple recycling sessions. We show how the combination of microfluidics and 3D printing can reduce costs and time, providing an efficient platform for particle production while offering a feasible cost-effective alternative to clean-room facility polydimethylsiloxane-based chip microfabrication.

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Section: Introductionmentioning

confidence: 99%

3D Printed Microfluidic Devices for Drug Release Assays

et al. 2020

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“…3D printing technology provides a manufacturing method to fabricate NGSs that had complex structures and was incorporated with pharmaceuticals. [11,34] The DLP-based 3D printing technique can print one layer with a high-resolution pattern in several seconds. [35] The self-adhesive bandage is a two-layer membrane composed of two different materials respectively.…”

Section: Discussionmentioning

confidence: 99%

A 3D‐Printed Self‐Adhesive Bandage with Drug Release for Peripheral Nerve Repair

et al. 2020

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Peripheral nerve injury is a common disease that often causes disability and challenges surgeons. Drug-releasable biomaterials provide a reliable tool to regulate the nerve healing-associated microenvironment for nerve repair. Here, a self-adhesive bandage is designed that can form a wrap surrounding the injured nerve to promote nerve regeneration and recovery. Via a 3D printing technique, the bandage is prepared with a special structure and made up of two different hydrogel layers that can adhere to each other by a click reaction. The nanodrug is encapsulated in one layer with a grating structure. Wrapping the injured nerve, the grating layer of the bandage is closed to the injured site. The drug can be mainly released to the inner area of the wrap to promote the nerve repair by improving the proliferation and migration of Schwann cells. In this study, the bandage is used to assist the neurorrhaphy for the treatment of complete sciatic nerve transection without obvious defect in rats. Results indicate that the self-adhesive capacity can simplify the installation process and the drug-loaded bandage can promote the repairing of injured nerves. The demonstrated 3D-printed self-adhesive bandage has potential application in assisting the neurorrhaphy for nerve repair.

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“…Stereolithography (SLA), one of the earliest 3D printing technologies ( Amin et al., 2016a ), works based on photochemical processes in which, using UV light and a digital micromirror device, a photocurable liquid polymer is cured in a layer-by-layer process to shape the product ( Amin et al., 2016a ; Ghaderinezhad et al., 2020 ; Quan et al., 2020 ; Yenilmez et al., 2016b ). Digital light processing (DLP) is another 3D printing technology, similar to SLA, which uses several mirrors along with a lightbulb, instead of UV light, to cure the photopolymer to shape the final structure ( Zhang et al., 2020 ). In addition, curing in the SLA method is in a point-to-point manner, whereas in DLP each layer is cured at once ( Ligon et al., 2017 ; Zhang et al., 2020 ).…”

Section: Fabrication Of Mnsmentioning

confidence: 99%

“…Digital light processing (DLP) is another 3D printing technology, similar to SLA, which uses several mirrors along with a lightbulb, instead of UV light, to cure the photopolymer to shape the final structure ( Zhang et al., 2020 ). In addition, curing in the SLA method is in a point-to-point manner, whereas in DLP each layer is cured at once ( Ligon et al., 2017 ; Zhang et al., 2020 ).…”

Section: Fabrication Of Mnsmentioning

confidence: 99%

3D-printed microneedles in biomedical applications

et al. 2021

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Conventional needle technologies can be advanced with emerging nano-and micro-fabrication methods to fabricate microneedles. Nano-/micro-fabricated microneedles seek to mitigate penetration pain and tissue damage, as well as providing accurately controlled robust channels for administrating bioagents and collecting body fluids. Here, design and 3D printing strategies of microneedles are discussed with emerging applications in biomedical devices and healthcare technologies. 3D printing offers customization, cost-efficiency, a rapid turnaround time between design iterations, and enhanced accessibility. Increasing the printing resolution, the accuracy of the features, and the accessibility of low-cost raw printing materials have empowered 3D printing to be utilized for the fabrication of microneedle platforms. The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine.

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Digital Light Processing Based Three-dimensional Printing for Medical Applications

Cited by 235 publications

References 73 publications

3D Printed Microfluidic Devices for Drug Release Assays

3D Printed Microfluidic Devices for Drug Release Assays

A 3D‐Printed Self‐Adhesive Bandage with Drug Release for Peripheral Nerve Repair

3D-printed microneedles in biomedical applications

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