Digital Pathology: A Tool for 21st Century Neuropathology

Guzmán, Miguel A.; Judkins, Alexander R.

doi:10.1111/j.1750-3639.2009.00264.x

Cited by 21 publications

(24 citation statements)

References 23 publications

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“…These systems have been followed by more sophisticated methods of image acquisition called whole slide imaging (or virtual microscopy) where the whole glass slide is converted into a digital form (whole slide images, WSI) allowing the examination of pathology specimen on a computer display with the aid of an image viewer 4 5. Scanners dedicated to scan glass slides and the creation of WSI became available more than a decade ago 6 7. WSI combine the features of both the previous telepathology systems (static and dynamic), providing high resolution images with unlimited access to the entire pathology specimen at different magnifications 8 9.…”

Section: Introductionmentioning

confidence: 99%

Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory

et al. 2012

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“…Several reviews have addressed the benefits and issues related to incorporating digital pathology into an anatomic pathology practice. [27][28][29][30][31][32] Our large validation study demonstrates substantial equivalence between the 2 platforms in key interpretive areas. Prospective studies using a design similar to that of our large multi-institutional study are needed to further validate our data regarding the comparison of WSI with OM in different tissue types.…”

Section: Commentmentioning

confidence: 99%

Multi-Institutional Comparison of Whole Slide Digital Imaging and Optical Microscopy for Interpretation of Hematoxylin-Eosin–Stained Breast Tissue Sections

Krishnamurthy¹,

Mathews²,

McClure³

et al. 2013

Archives of Pathology & Laboratory Medicine

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Context.-Whole slide imaging (WSI) is now used for educational purposes, for consultation, and for archiving and quantitation of immunostains. However, it is not routinely used for the primary diagnosis of hematoxylineosin-stained tissue sections.Objective.-To compare WSI using the Aperio digital pathology system (Aperio Technologies, Inc, Vista, California) with optical microscopy (OM) for the interpretation of hematoxylin-eosin-stained tissue sections of breast lesions.Design.-The study was conducted at 3 clinical sites; 3 breast pathologists interpreted 150 hematoxylin-eosinstained slides at each site, 3 times each by WSI and 3 times each by OM. For WSI, slides were scanned using an Aperio ScanScope and interpreted on a computer monitor using Aperio ImageScope software and Aperio Spectrum data management software. Pathologic interpretations were recorded using the College of American Pathologists breast checklist. WSI diagnoses were compared with OM diagnoses for accuracy, precision (interpathologist variation), and reproducibility (intrapathologist variation). Results were considered accurate only if the interpretation matched exactly between WSI and OM. The proportion of accurate results reported by each pathologist was expressed as a percentage for the comparison of the 2 platforms.Results.-The accuracy of WSI for classifying lesions as not carcinoma or as noninvasive (ductal or lobular) or invasive (ductal, lobular, or other) carcinoma was 90.5%. The accuracy of OM was 92.1%. The precision and reproducibility of WSI and OM were determined on the basis of pairwise comparisons (3 comparisons for each slide, resulting in 36 possible comparisons). The overall precision of WSI was 90.5% in comparison with 92.1% for OM; reproducibility of WSI was 91.6% in comparison with 94.5% for OM, respectively.Conclusions.-In this study, we demonstrated that WSI and OM have similar accuracy, precision, and reproducibility for interpreting hematoxylin-eosin-stained breast tissue sections. Further clinical studies using routine surgical pathology specimens would be useful to confirm these findings and facilitate the incorporation of WSI into diagnostic practice. (Arch Pathol Lab Med. 2013;137:1733-1739 doi: 10.5858/arpa.2012-0437-OA) T he practice of surgical pathology relies on image-based light microscopy diagnosis, which enables the detailed evaluation of the cytologic and architectural features of hematoxylin-eosin (H&E)-stained tissue sections. Significant recent technological advancements have allowed for the acquisition and storage of high-quality digital images. Several commercially available platforms are available for scanning H&E-stained tissue sections, generating digital whole slide images (WSI) for viewing and interpretation. The field of digital pathology is rapidly evolving toward the creation of a digital environment for interpreting and managing pathologic information contained in a glass slide.Several applications of digital pathology are currently being embraced by pathologists. Whole slide imaging is ...

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“…[10] In addition, this technology potentially allows sparse material to be used by increasing numbers of students. [11] Histopathology from the dissecting room: Are cadavers a suitable source of educationally useful histopathology specimens?…”

Section: Introductionmentioning

confidence: 99%

Histopathology from the dissecting room: are cadavers a suitable source of educationally useful histopathology specimens?

Wood¹,

Whiten²,

McVee³

et al. 2015

Anatomy

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Objectives: The requirement of the General Medical Council to 'reduce factual overload' has led to the development of integrated curricula in which the knowledge base related to basic medical sciences has been greatly restricted. The time allocated to pathology teaching in medical schools has been decreased. The challenge for educators is to introduce effective methods of learning pathology into an integrated, student-centred curriculum. The aim of this study is to assess the tissue derived from cadaveric material and report its potential for use in teaching histopathology. Methods:We have previously reported how we use cadavers' medical histories when introducing students to their 'first patient'. The medical histories of the seventeen cadavers that were dissected during one academic session were reviewed for evidence of reported pathology. During dissection unexpected pathological findings were noted. Standard histological processing was carried out on pathological tissue from the cadavers, a prosection and a specimen which was displayed in a museum pot. These specimens were then assessed for educational value by an expert clinical histopathologist. Results:We find that the availability of a real medical history combined with gross and microscopic pathology encourages integration of basic medical sciences and promotes the learning of both gross and microscopic pathology in the dissecting room. Conclusion:The dissecting room provides ample material to introduce pathological concepts to undergraduate medical students and this material is a valuable resource for teaching histopathology.

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Digital Pathology: A Tool for 21st Century Neuropathology

Cited by 21 publications

References 23 publications

Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory

Whole slide images as a platform for initial diagnostics in histopathology in a medium-sized routine laboratory

Multi-Institutional Comparison of Whole Slide Digital Imaging and Optical Microscopy for Interpretation of Hematoxylin-Eosin–Stained Breast Tissue Sections

Histopathology from the dissecting room: are cadavers a suitable source of educationally useful histopathology specimens?

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