Digital squamous cell carcinoma and association with diverse high-risk human papillomavirus types

Gormley, Rachel H.; Groft, Caroline M.; Miller, Christopher J.; Kovarik, Carrie L.

doi:10.1016/j.jaad.2009.10.044

Cited by 39 publications

(33 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gormley et al [20] reported 7 patients, including 4 HIV-positive patients, who presented with 10 lesions of digital squamous cell carcinoma in situ . Multiple high-risk oncogenic subtypes were found, including HPVs 16, 33, 51, and 73.…”

Section: Discussionmentioning

confidence: 99%

“…Their case series highlights the diversity of oncogenic HPV types that may be associated with digital squamous cell carcinomas although the majority of reports linking HPV and digital squamous cell carcinomas have implicated the HPV 16 subtype. Because the high rate of recurrence of digital squamous cell carcinomas may be a result of the persistence of oncogenic HPV at the margin of resection, aggressive treatment of individual lesions and of genital reservoirs for HPV in patients and their sexual partners is warranted [20]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases

Park

Kim

Min

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

Human papillomavirus (HPV) infection has been demonstrated in some of the nonmelanoma skin cancers as well as in precancerous lesions. Multiple infections of mucosal high-risk HPV may contribute to the onset of digital Bowen's disease through, if any, digital-genital transmission. We screened for the presence of the mucosal HPV DNA in patients with extragenital Bowen's disease (n = 30), squamous cell carcinoma (n = 11), bowenoid papulosis (n = 9), verrucous carcinoma (n = 1), actinic keratosis (n = 5), and basal cell carcinoma (n = 5). We used a PANArray HPV Genotyping Chip for high-risk and low-risk mucosal types. Genotyping data was confirmed using a conventional direct DNA sequencing method. Two cases of extragenital Bowen's disease were positive for types 16 and 33 of mucosal HPV, respectively. None of the squamous cell carcinoma cases were positive. Neither patients with digital Bowen's disease (n = 5) nor those with squamous cell carcinoma (n = 3) showed any mucosal high-risk HPV. Mucosal high-risk HPV DNA was confirmed in 5 (55.6%) of the 9 patients with bowenoid papulosis. HPV 16 was most prevalent (n = 3), while the DNA of HPVs 35 and 67 was detected in one sample for each of the two types. Our study demonstrated that two (6.7%) of the patients with 30 extragenital Bowen's disease were positive for types 16 and 33 of mucosal HPV, respectively. HPVs belonging to the mucosal high-risk group may participate in the development of extragenital Bowen's disease. However, we could not find any relationship between the mucosal high-risk HPV and Bowen's disease or squamous cell carcinoma in the fingers.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases

Park

Kim

Min

et al. 2013

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Interestingly, in case 3 of our patient series periungual BD was positive for the rare α-HPV type 73, and advanced HIV disease (CDC B3) was diagnosed 18 months after onset of BD of the nail unit. Based on the limited number of reported HIV-positive patients with ungual BD, it is striking that α-HPV type 73 DNA could be detected in 3 out of 7 HPV-73-positive cases and the rare α-HPV type 26 in 3 out of 3 HPV-26-positive cases with BD/SCC of the nail apparatus [19,20,21,22]. Therefore, these data support the hypothesis that HIV-related immune suppression might predispose for the acquisition of rare HPV types [21,22].…”

Section: Discussionmentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

et al. 2011

View full text Add to dashboard Cite

Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition. Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed. Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected. Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.

show abstract

“…17,18 However, HPV16 was also detected in human skin SCCs, indicating that this HPV type is competent at inducing malignant skin lesions. 19,20 HPV16 encodes oncoproteins E6 and E7, which inactivate several proteins, the retinoblastoma (Rb) protein family and the tumor-suppressor protein p53 being the best characterized of these. 21 The impact of HPV16 E6 and E7 expression on skin cancer was demonstrated through the generation of the K14-HPV16 mouse model.…”

Section: Introductionmentioning

confidence: 99%

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

et al. 2012

View full text Add to dashboard Cite

Epidermal keratinocytes and hair follicle (HF) stem cells (SCs) expressing oncogenes are competent at developing squamous cell carcinomas (SCCs) in epidermis and HFs, respectively. To determine whether bulge and hair germ (HG) SCs from HF contribute to SCC generation at distant epidermis, the most frequent epidermal region where these lesions arise in human skin, we used a skin cancer mouse model expressing E6 and E7 oncoproteins from Human papillomavirus (HPV) 16 in SCs and basal keratinocytes. This previously described mouse model recapitulates the human skin papillomavirus-induced SCC pathology. We show that E6 and E7 expression promote the expansion of keratin 15 (K15)-expressing cells. These K15(+) aberrant cells exhibit some HGSC markers and diminished expression of Tcf3 and Sox9 hair SC specification genes, which are accumulated in HFs and mislocalized to interfollicular epidermis. Leucine-rich G-protein-coupled receptor 5 (Lgr5)-expressing SCs, localized in the bulge and HG, are the origin of the expanded K15(+) cell population. A large subset of the Lgr5(+) SC progeny, expressing K15 and P-cadherin, is aberrantly mobilized to the upper region of HFs and the epidermis, and accumulates at E6/E7-induced pre-neoplastic lesions and epidermal tumors. These findings indicate that aberrant accumulation of altered SCs in HFs and their subsequent migration to the epidermis contribute to HPV-induced tumor development.

show abstract

Digital squamous cell carcinoma and association with diverse high-risk human papillomavirus types

Cited by 39 publications

References 30 publications

Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases

Low Rate of Detection of Mucosal High-Risk-Type Human Papillomavirus in Korean Patients with Extragenital Bowen's Disease and Squamous Cell Carcinoma, Especially in Digital Cases

High-Risk Human Papillomavirus Infection in Bowen’s Disease of the Nail Unit: Report of Three Cases and Review of the Literature

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis

Contact Info

Product

Resources

About