Background: This paper examines scientific papers in the field of digital twins to explore the different areas of application in supply chains. Methods: Using a machine learning-based topic modeling approach, this study aims to provide insights into the key areas of supply chain management that benefit from digital twin capabilities. Results: The research findings highlight key priorities in the areas of infrastructure, construction, business, technology, manufacturing, blockchain, and agriculture, providing a comprehensive perspective. Conclusions: Our research findings confirm several recommendations. First, the machine learning-based model identifies new areas that are not addressed in the human review results. Second, while the human review results put more emphasis on practicality, such as management activities, processes, and methods, the machine learning results pay more attention to macro perspectives, such as infrastructure, technology, and business. Third, the machine learning-based model is able to extract more granular information; for example, it identifies core technologies beyond digital twins, including AI/reinforcement learning, picking robots, cybersecurity, 5G networks, the physical internet, additive manufacturing, and cloud manufacturing.