Digital Technology Tools to Examine Patient Adherence to a Prescription-Only Omega-3 Polyunsaturated Fatty Acid Therapy To Mitigate Cardiovascular Risk: Protocol for a Prospective Observational Study and Preliminary Demographic Analysis

Arutyunov, G. P.; Arutyunov, A G; Ageev, F. T.; Фофанова, Т.В.

doi:10.2196/29061

Cited by 3 publications

(5 citation statements)

References 36 publications

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“…A comprehensive description of the methodology of the DIAPAsOn study has previously been published, including baseline demographic data [ 20 ]. Briefly, DIAPAsOn was a prospective observational study conducted at >100 centers in the Russian Federation that was devised to examine adherence to a prescription of OM3EE as either a secondary preventive medical therapy (at a dose of 1 g/day) for patients with a history of recent MI or for blood lipid regulation (at a dose of 2-4 g/day) in patients with endogenous hypertriglyceridemia insufficiently responsive to dietary modification or drug therapy.…”

Section: Methodsmentioning

confidence: 99%

“…The electronic patient engagement and data collection system used in DIAPAsOn was developed in collaboration with the medical online platform Rosmed.info, which has wide-ranging experience in the development and operation of mobile health applications in the Russian Federation. A fuller description of the system used in DIAPAsOn is featured in a separate paper on the study’s methodology [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…The emergence of widely available digital and internet technologies with the potential to provide immediate bidirectional communication between health care professionals (ie, doctors, nurses, and pharmacists) and patients may be an important new resource for promoting long-term adherence to therapies [ 19 ]. The DIAPAsOn study was devised to explore patient adherence to OM3EE therapy through the medium of digital technology tools [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study

Arutyunov¹,

Arutyunov²,

Ageev³

et al. 2022

JMIR Cardio

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Background Maintaining sustained adherence to medication for optimal management of chronic noninfectious diseases, such as atherosclerotic vascular disease, is a well-documented therapeutic challenge. Objective The DIAPAsOn study was a 6-month, multicenter prospective observational study in the Russian Federation that examined adherence to a preparation of highly purified omega-3 polyunsaturated fatty acids (Omacor) in 2167 adult patients with a history of recent myocardial infarction or endogenous hypertriglyceridemia. Methods A feature of DIAPAsOn was the use of a bespoke electronic patient engagement and data collection system to monitor adherence. Adherence was also monitored by enquiry at clinic visits. A full description of the study’s aims and methods has appeared in JMIR Research Protocols. Results The net average reduction from baseline in both total and low-density lipoprotein cholesterol was approximately 1 mmol/L and the net average increase in high-density lipoprotein cholesterol was 0.2 (SD 0.53) mmol/L (P<.001 for all outcomes vs baseline). The mean triglyceride level was 3.0 (SD 1.3) mmol/L at visit 1, 2.0 (SD 0.9) mmol/L at visit 2, and 1.7 (SD 0.7) mmol/L at visit 3 (P<.001 for later visits vs visit 1). The percentage of patients with a triglyceride level <1.7 mmol/L rose from 13.1% (282/2151) at baseline to 54% (1028/1905) at the end of the study. Digital reporting of adherence was registered by 8.3% (180/2167) of patients; average scores indicted poor adherence. However, a clinic-based enquiry suggested high levels of adherence. Data on health-related quality of life accrued from digitally engaged patients identified improvements among patients reporting high adherence to study treatment, but patient numbers were small. Conclusions The lipid and lipoprotein findings indicate that Omacor had nominally favorable effects on the blood lipid profile. Less than 10% of patients enrolled in DIAPAsOn used the bespoke digital platform piloted in the study, and the level of self-reported adherence to medication by these patients was also low. Reasons for this low uptake and adherence are unclear. Better adherence was recorded in clinical reports. Trial Registration ClinicalTrials.gov NCT03415152; https://clinicaltrials.gov/ct2/show/NCT03415152

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study

Arutyunov¹,

Arutyunov²,

Ageev³

et al. 2022

JMIR Cardio

Self Cite

View full text Add to dashboard Cite

show abstract

“…Overview A comprehensive description of the methodology of the DIAPAsOn study has been published, including baseline demographic data [20].…”

Section: Methodsmentioning

confidence: 99%

“…The electronic patient engagement and data collection system used in DIAPAsOn was developed in collaboration with the medical online platform ROSMED.INFO (Moscow, Russian Federation; www.rosmed.info), which has wide-ranging experience in the development and operation of mobile health applications in the Russian Federation. A fuller description of the system used in DIAPAsOn featured in the separate publication of methodology [20].…”

Section: Schedule Of Visits and Data Collectionmentioning

confidence: 99%

Use of digital technology tools to characterize patient adherence to prescription-grade omega-3 polyunsaturated fatty acid therapy: Primary results of the DIAPAsOn prospective observational study

Arutyunov

Ageev

et al. 2022

Preprint

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Background, objectives and methods: DIAPAsOn was a 6-month prospective observational multicenter study in the Russian Federation that examined adherence to a preparation of highly purified omega-3 polyunsaturated fatty acids (OMACOR) in adult patients with a history of recent myocardial infarction or endogenous hypertriglyceridemia. A full description of the study aims and methods has appeared in JMIR Res Protoc. A feature of DIAPAsOn was the use of a bespoke electronic patient engagement and data collection system. Results: The net average reduction from baseline in both total and low-density lipoprotein cholesterol was approximately 1 mmol/L and the net average increment in high-density lipoprotein cholesterol was 0.2+/-0.53 mmol/L. Mean triglyceride levels declined by ~1.3 mmol/, from an initial level of 2.99+/-1.29 mmol/L to 1.67+/- 0.67 mmol/L. The percentage of patients with triglyceride <1.7 mmol/L rose from 13.1% at baseline to 54% at study-end. Digital reporting of adherence was registered by 8.3% of patients (n=180) and average scores indicted poor adherence. However, clinic-based enquiry suggested high levels of adherence. Data on health-related quality of life accrued from digitally-engaged patients identified improvements among patients reporting high adherence to study treatment, but patient numbers were small. Conclusions: The lipid and lipoprotein findings indicate that OMACOR had nominally favorable effects on the blood lipid profile. Less than 10% of patients enrolled in DIAPAsOn used the bespoke digital platform piloted in the study and the level of self-reported adherence to medication by those patients was also low. Reasons for this low uptake and adherence are unclear. Better adherence was recorded by clinical report.

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Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study (Preprint)

Arutyunov¹,

Arutyunov²,

Ageev³

et al. 2022

Preprint

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BACKGROUND DIAPAsOn was a 6-month prospective observational multicenter study in the Russian Federation that examined adherence to a preparation of highly purified omega-3 polyunsaturated fatty acids (OMACOR) in adult patients with a history of recent myocardial infarction or endogenous hypertriglyceridemia. OBJECTIVE A full description of the study’s aims and methods has appeared in JMIR Res Protoc. METHODS A feature of DIAPAsOn was the use of a bespoke electronic patient engagement and data collection system. RESULTS The net average reduction from baseline in both total and low-density lipoprotein cholesterol was approximately 1 mmol/L and the net average increment in high-density lipoprotein cholesterol was 0.2+/-0.53 mmol/L. Mean triglyceride levels declined by ~1.3 mmol/, from an initial level of 2.99+/-1.29 mmol/L to 1.67+/- 0.67 mmol/L. The percentage of patients with triglyceride <1.7 mmol/L rose from 13.1% at baseline to 54% at study-end. Digital reporting of adherence was registered by 8.3% of patients (n=180) and average scores indicted poor adherence. However, clinic-based enquiry suggested high levels of adherence. Data on health-related quality of life accrued from digitally-engaged patients identified improvements among patients reporting high adherence to study treatment, but patient numbers were small. CONCLUSIONS The lipid and lipoprotein findings indicate that OMACOR had nominally favorable effects on the blood lipid profile. Less than 10% of patients enrolled in DIAPAsOn used the bespoke digital platform piloted in the study and the level of self-reported adherence to medication by those patients was also low. Reasons for this low uptake and adherence are unclear. Better adherence was recorded by clinical report. CLINICALTRIAL NCT03415152

show abstract

Digital Technology Tools to Examine Patient Adherence to a Prescription-Only Omega-3 Polyunsaturated Fatty Acid Therapy To Mitigate Cardiovascular Risk: Protocol for a Prospective Observational Study and Preliminary Demographic Analysis

Cited by 3 publications

References 36 publications

Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study

Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study

Use of digital technology tools to characterize patient adherence to prescription-grade omega-3 polyunsaturated fatty acid therapy: Primary results of the DIAPAsOn prospective observational study

Use of Digital Technology Tools to Characterize Adherence to Prescription-Grade Omega-3 Polyunsaturated Fatty Acid Therapy in Postmyocardial or Hypertriglyceridemic Patients in the DIAPAsOn Study: Prospective Observational Study (Preprint)

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