Digital Therapeutics in Hypertension: Evidence and Perspectives

Kario, Kazuomi; Harada, Noriko; Okura, Ayako

doi:10.1161/hypertensionaha.122.19414

Cited by 60 publications

(26 citation statements)

References 70 publications

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“…Hypertension accounts for the largest number of deaths worldwide and is particularly harmful to the blood vessel, heart, kidney, and brain. Hypertension is closely associated with unhealthy dietary habits, such as heavy alcohol consumption, excessive intake of sodium salt, and low potassium diet ( 3 ). A better understanding of the relationship between the risk of hypertension and dietary habits is essential to prevent the onset and development of hypertension.…”

Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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AimsWe aim to investigate the association of the Dietary Inflammatory Index (DII) with the prevalence of hypertension in a large multiracial population in the United States.MethodsParticipants from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were included in this cross-sectional study. Dietary information was obtained and used to calculate DII. Blood pressures of participants were measured by experienced examiners. The NHANES used the method of “stratified multistage probability sampling,” and this study is a weight analysis following the NHANES analytic guidance. Weight logistic regression analysis was adopted to investigate the association of hypertension with DII. Least Absolute Shrinkage and Selection Operator (LASSO) regression was carried out to screen the most important dietary factors associated with the risk of hypertension. Moreover, a nomogram model based on key dietary factors was established; the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic power of the nomogram model for screening hypertension risk.ResultsA total of 45,023 participants were included in this study, representing 191 million residents in the United States. Participants with hypertension had an elevated DII compared with those without hypertension. Weight logistic regression showed that an increment of DII was strongly associated with hypertension after adjusting for confounding factors. The nomogram model, based on key dietary factors screened by LASSO regression, showed a favorable discriminatory power with an area under the curve (AUC) of 78.5% (95% CI: 78.5%–79.3%). Results of the sensitivity analysis excluding participants who received any drug treatment were consistent with those in the main analysis.ConclusionAn increment of DII is associated with the risk of hypertension. For better prevention and treatment of hypertension, more attention should be paid to controlling dietary inflammation.

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Section: Introductionmentioning

confidence: 99%

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

et al. 2023

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“…A metaanalysis on the effect of home BP monitoring demonstrated that home BP monitoring with the education and/or consultation significantly lower BP [20]. In 2021, the first randomized control trial of digital therapeutics (application) for hypertension (HERB-DH1) demonstrated the significant 24-h SBP reduction, compared with control group [21,22]. Both digital therapeutics group and control group received doctor's routine lifestyle education with home BP morning.…”

Section: Proposal Of Home Bp-centered Approachmentioning

confidence: 99%

“…Both digital therapeutics group and control group received doctor's routine lifestyle education with home BP morning. Morning home SBP significantly reduced by 10.9 mmHg in digital therapeutics group, and by 6.2 mmHg in the control group (the group-difference: 4.3 mmHg, p < 0.001) [21,22]. In 2022, in Japan, the digital therapeutics of hypertension was first approved by regulatory authority in the condition of combined use of home BP monitoring [23].…”

Section: Proposal Of Home Bp-centered Approachmentioning

confidence: 99%

Lifetime home BP-centered approach is the core from onset to aggravation of hypertension

2023

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“…Digital Therapeutics (DTx), a subset of digital health solutions, provides evidence-based therapeutic interventions. To prevent, manage, or treat a medical ailment, DTx leverages state-of-the-art artificial intelligence techniques to replace or enhance a variety of established psychological approaches to therapy ( 6 ). Artificial intelligence techniques have been widely employed in a variety of fields and have already been used in combination with drugs or other therapies to improve patient care and health outcomes ( 7 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Enhancing the conversational agent with an emotional support system for mental health digital therapeutics

et al. 2023

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As psychological diseases become more prevalent and are identified as the leading cause of acquired disability, it is essential to assist people in improving their mental health. Digital therapeutics (DTx) has been widely studied to treat psychological diseases with the advantage of cost savings. Among the techniques of DTx, a conversational agent can interact with patients through natural language dialog and has become the most promising one. However, conversational agents' ability to accurately show emotional support (ES) limits their role in DTx solutions, especially in mental health support. One of the main reasons is that the prediction of emotional support systems does not extract effective information from historical dialog data and only depends on the data derived from one single-turn interaction with users. To address this issue, we propose a novel emotional support conversation agent called the STEF agent that generates more supportive responses based on a thorough view of past emotions. The proposed STEF agent consists of the emotional fusion mechanism and strategy tendency encoder. The emotional fusion mechanism focuses on capturing the subtle emotional changes throughout a conversation. The strategy tendency encoder aims at foreseeing strategy evolution through multi-source interactions and extracting latent strategy semantic embedding. Experimental results on the benchmark dataset ESConv demonstrate the effectiveness of the STEF agent compared with competitive baselines.

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Digital Therapeutics in Hypertension: Evidence and Perspectives

Cited by 60 publications

References 70 publications

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

The dietary inflammatory index and its association with the prevalence of hypertension: A cross-sectional study

Lifetime home BP-centered approach is the core from onset to aggravation of hypertension

Enhancing the conversational agent with an emotional support system for mental health digital therapeutics

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