Interoperability has become crucial in the world of electronic health records, allowing for seamless data exchange and integration across diverse settings. It facilitates the integration of disparate systems, ensures that patient records are accessible, and enhances the care-delivery process. The current interoperability landscape of electronic health records is saddled with challenges hindering efficient interoperability. Existing interoperability frameworks have not adequately addressed many of the challenges relating to data exchange, security and privacy. To address these challenges, the TASIPPS (Technical and Semantic Interoperability, Preserving Privacy and Security) framework is proposed as a comprehensive approach to achieving efficient interoperability. The TASIPPS framework integrates robust security and privacy measures, providing real-time access to electronic health records that enable precise diagnoses, timely treatment plans and improved patient outcomes. The TASIPPS framework offers a holistic and effective solution to healthcare interoperability challenges. A comparison of the framework with existing frameworks showed that the TASIPPS framework addresses key limitations in privacy, security, and scalability, while providing enhanced interoperability across distinct healthcare systems, positioning it as a more comprehensive solution for modern healthcare needs.