Preventive strategies for the conservation of heritage sites have gradually been preferred to curative approaches because of their ability to maintain their significance. Furthermore, most experts now agree that conservation management of heritage places based on a common understanding of their cultural values is essential to address all the particularities of their contexts. Recently, significant research has demonstrated the potential of Heritage Building Information Modelling (HBIM) for the collaborative data management in conjunction with conservation projects. The recent development of HBIM web platforms illustrates the value of strengthening the link between the digital model and the physical realm of heritage assets. This paper advocates the application of Digital Twin’s (DT) principles, using HBIM models as a digital replica, to support the preventive conservation of heritage places. Based on an extensive literature review, a comprehensive framework that integrates the DT into the management plan process for the preventive conservation of built heritage is proposed. Several recommendations for its implementation are finally discussed, such as the identification of tangible features of significance, the threats associated with their integrity and the corresponding mitigation strategies, with particular emphasis on the value assessment process. The result is a data model for structuring information on preventive conservation strategies. This framework provides the basis for future implementation and demonstrates the need for a DT approach in this context.