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“…Serum of uremic patients interfered with the radiorubidium assays for digitalis (10); this observation and the reduced inotropic dose-response relationship to digoxin in uremic animals (11) led several authors to the conclusion that in uremic animals endogenous digoxin-like substances were present, presumably in supranormal concentrations. The presence of endogenous digitalis in normal mammals had been postulated half a century ago (12).…”
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confidence: 99%
“…Serum of uremic patients interfered with the radiorubidium assays for digitalis (10); this observation and the reduced inotropic dose-response relationship to digoxin in uremic animals (11) led several authors to the conclusion that in uremic animals endogenous digoxin-like substances were present, presumably in supranormal concentrations. The presence of endogenous digitalis in normal mammals had been postulated half a century ago (12).…”
mentioning
confidence: 99%
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