This research demonstrates the beginning of the trajectory of the economic development of the Bukhara region during digitalization. Such indicators as the size of resident working-age population, the number of enterprises and organizations connected to the Internet, the length of fiber-optic communication lines, which are the factors affecting the growth of the gross regional product, have been analyzed based on the multifactorial econometric models. This research, along with the relevant literature review, provides opinions, conclusions and proposals of the authors of this research.