The article is devoted to the spatial organization of the regional professional education system under new economic conditions: digitalization processes, new industrialization, the beginning of the information era, etc. The factors of the functioning and development of the regional system of professional education, that affect the dynamics of its spatial organization under changing conditions, are identified. The provisions about the ongoing process of transformation of the studied system through the introduction of innovative elements in the professional education system, that change its value at the regional and country levels, are argued.