In recent years, computer-aided design (CAD) and computeraided manufacturing (CAM) have been widely integrated into clinical dentistry, particularly in the field of prosthetics. Unlike conventional methods, the new workflows of these CAD/CAM systems enable the fabrication of high-performance restorations [1,2]. Duret et al., in 1988, first reported the use of CAD/CAM technology for prosthesis fabrication [3]. Since the 1980s, many researchers have focused on the practical applications of these systems [4][5][6][7]. The advantages of CAD/CAM systems include increased productivity, lower costs, easier data management, and shorter treatment durations, which are beneficial for both dental surgeons and patients [8][9][10]. This technology has already been applied to fixed prosthetic appliances, such as inlays, crowns, and implant prosthetic components [11][12][13][14]. However, removable prostheses consist of several metallic (clasps, frameworks) and non-metallic (denture bases and artificial teeth) components, which render the application of the CAD/CAM system difficult. Therefore, the fabrication of removable prostheses using CAD/CAM has been delayed [15]. Currently, CAD/CAM complete dentures are fabricated by two companies (AvaDent; Global Dental Science, Scottsdale, AZ and DENTCA; Dentca Inc., Los Angeles, CA), and these dentures are available for use in edentulous patients [16][17][18][19][20][21][22][23]. Both companies allow definitive dentures to be fabricated in a few visits, and the dental materials, techniques, and fabrication processes have been established and standardized. The fabrication process for DENTCA dentures involves 3D printing technology (3DP) [24]. CAD/CAM dentures have been shown to achieve greater patient satisfaction than conventional complete dentures [19][20][21][22]. However,