The purpose of this paper is to discuss the challenges that appear in maritime human resource management, in the face of the digitalized environment in maritime business, due to the diffusion of new technologies, such as big data analytics, blockchain technology, and future MASS technology. The current study is based on a systematic review of the relevant literature attempting to respond to the analysis of the challenges described above. The study reveals that existing scientific interest concentrates on the training and education of the maritime workforce, the new skills required as well as the possible loss of traditional jobs and the creation of new ones, while mainly examining the seagoing personnel. However, limited attention has been paid to the practices of human resource management, which could facilitate the transition to the new era of maritime business. This study aims at contributing to the research in the field of Maritime HRM by revealing gaps in existing literature and suggesting areas for future research as well as new methodological approaches in addressing these gaps.