Diglucosyl-glycerolipids from the marine sponge-associated Bacillus pumilus strain AAS3: their production, enzymatic modification and properties

Ramm, Werner; Schatton, Wolfgang; Wagner‐Döbler, Irene; Wray, Victor; Nimtz, Manfred; Tokuda, Harukuni; Enjyo, Fumio; Nishino, Hoyoku; Beil, Winfried; Heckmann, Rolf; Verena, Lurtz; Lang, Siegmund

doi:10.1007/s00253-003-1471-8

Cited by 22 publications

(3 citation statements)

References 25 publications

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“…Antitumor promoting studies showed that the diglucosyl-glycerol GG11 strongly inhibited the growth of the tumor cell lines HM02 and Hep G2. Thus, it indicates the potential inhibitory activity of the compound with carbohydrate/glycerol backbone [116]. Twenty nine marine bacterial strains were isolated from the sponge Hymeniacidon perlevis at Nanji Island (China Sea), and the antimicrobial screening showed that eight strains inhibited the growth of terrestrial microorganisms.…”

Section: Sponges and Associated Microbes Involved In Drug Productionmentioning

confidence: 99%

Marine Drugs from Sponge-Microbe Association—A Review

2010

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The subject of this review is the biodiversity of marine sponges and associated microbes which have been reported to produce therapeutically important compounds, along with the contextual information on their geographic distribution. Class Demospongiae and the orders Halichondrida, Poecilosclerida and Dictyoceratida are the richest sources of these compounds. Among the microbial associates, members of the bacterial phylum Actinobacteria and fungal division Ascomycota have been identified to be the dominant producers of therapeutics. Though the number of bacterial associates outnumber the fungal associates, the documented potential of fungi to produce clinically active compounds is currently more important than that of bacteria. Interestingly, production of a few identical compounds by entirely different host-microbial associations has been detected in both terrestrial and marine environments. In the Demospongiae, microbial association is highly specific and so to the production of compounds. Besides, persistent production of bioactive compounds has also been encountered in highly specific host-symbiont associations. Though spatial and temporal variations are known to have a marked effect on the quality and quantity of bioactive compounds, only a few studies have covered these dimensions. The need to augment production of these compounds through tissue culture and mariculture has also been stressed. The reviewed database of these compounds is available at www.niobioinformatics.in/drug.php.

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Section: Sponges and Associated Microbes Involved In Drug Productionmentioning

confidence: 99%

Marine Drugs from Sponge-Microbe Association—A Review

2010

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“…Glycoglycerolipids related to testacosides have been isolated from cultures of a wide variety of bacteria obtained from different sources, such as the pathogen Rothia mucilaginosa (Pasciak et al 2004), Bacillus pumilus (Ramm et al 2004 ), Microccocus luteus (Pakkiri et al 2004 ), and the marine-derived Bacillus licheniformis 09IDYM23 (Tareq et al 2015 ). Unusual glycoglycerolipids diacylated at both 3 and 6′ positions have already been isolated from bacteria.…”

Section: Discussionmentioning

confidence: 99%

Testacosides A–D, glycoglycerolipids produced by Microbacterium testaceum isolated from Tedania brasiliensis

Quintana-Bulla,

Tonon,

Michaliski

et al. 2024

Appl Microbiol Biotechnol

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Marine bacteria living in association with marine sponges have proven to be a reliable source of biologically active secondary metabolites. However, no studies have yet reported natural products from Microbacterium testaceum spp. We herein report the isolation of a M. testaceum strain from the sponge Tedania brasiliensis. Molecular networking analysis of bioactive pre-fractionated extracts from culture media of M. testaceum enabled the discovery of testacosides A–D. Analysis of spectroscopic data and chemical derivatizations allowed the identification of testacosides A–D as glycoglycerolipids bearing a 1-[α-glucopyranosyl-(1 → 3)-(α-mannopyranosyl)]-glycerol moiety connected to 12-methyltetradecanoic acid for testacoside A (1), 14-methylpentadecanoic acid for testacoside B (2), and 14-methylhexadecanoic acid for testacosides C (3) and D (4). The absolute configuration of the monosaccharide residues was determined by 1H-NMR analysis of the respective diastereomeric thiazolidine derivatives. This is the first report of natural products isolated from cultures of M. testaceum. Key points • The first report of metabolites produced by Microbacterium testaceum. • 1-[α-Glucopyranosyl-(1 → 3)-(α-mannopyranosyl)]-glycerol lipids isolated and identified. • Microbacterium testaceum strain isolated from the sponge Tedania brasiliensis. Graphical abstract

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“…Consequently, there is a pressing need to intensify the search for novel biosurfactant-producing microorganisms. They can be found in soil [42][43][44][45], oil [46][47][48][49][50][51], water [52][53][54][55], and food [56][57][58][59]. The synthesis of biosurfactants is influenced by various factors, including watersoluble/insoluble carbon sources, nitrogen sources, pH, temperature, carbon-to-nitrogen (C/N) ratio, agitation, and oxygen availability [60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Potential of microbial-derived biosurfactants for oral applications–a systematic review

Khairunnisa,

Tuygunov,

Cahyanto

et al. 2024

BMC Oral Health

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Background Biosurfactants are amphiphilic compounds produced by various microorganisms. Current research evaluates diverse types of biosurfactants against a range of oral pathogens. Objectives This systematic review aims to explore the potential of microbial-derived biosurfactants for oral applications. Methodology A systematic literature search was performed utilizing PubMed-MEDLINE, Scopus, and Web of Science databases with designated keywords. The results were registered in the PROSPERO database and conducted following the PRISMA checklist. Criteria for eligibility, guided by the PICOS framework, were established for both inclusion and exclusion criteria. The QUIN tool was used to assess the bias risk for in vitro dentistry studies. Results Among the initial 357 findings, ten studies were selected for further analysis. The outcomes of this systematic review reveal that both crude and purified forms of biosurfactants exhibit antimicrobial and antibiofilm properties against various oral pathogens. Noteworthy applications of biosurfactants in oral products include mouthwash, toothpaste, and implant coating. Conclusion Biosurfactants have garnered considerable interest and demonstrated their potential for application in oral health. This is attributed to their surface-active properties, antiadhesive activity, biodegradability, and antimicrobial effectiveness against a variety of oral microorganisms, including bacteria and fungi.

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Diglucosyl-glycerolipids from the marine sponge-associated Bacillus pumilus strain AAS3: their production, enzymatic modification and properties

Cited by 22 publications

References 25 publications

Marine Drugs from Sponge-Microbe Association—A Review

Marine Drugs from Sponge-Microbe Association—A Review

Testacosides A–D, glycoglycerolipids produced by Microbacterium testaceum isolated from Tedania brasiliensis

Potential of microbial-derived biosurfactants for oral applications–a systematic review

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