Digoxin and its Na+/K+-ATPase-targeted actions on cardiovascular diseases and cancer

Ren, Yulin; Anderson, Andrew T.; Meyer, Gunnar; Lauber, Kaitlyn M.; Gallucci, Judith C.; Douglas Kinghorn, A.

doi:10.1016/j.bmc.2024.117939

Bioorganic & Medicinal Chemistry

2024

DOI: 10.1016/j.bmc.2024.117939

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Digoxin and its Na+/K+-ATPase-targeted actions on cardiovascular diseases and cancer

Yulin Ren,

Andrew T. Anderson,

Gunnar Meyer

et al.

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Nanosurgery and bioengineered structural regenerative protocols for the treatment of human knee meniscal tears: a double-blind randomized controlled study of a novel regenerative method

Wasilczyk,

Wasilczyk

2024

Regenerative Medicine Reports

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In recent years, global research has increasingly focused on regenerative treatments for meniscal injuries of the knee joint. However, there is still no consensus on whether regenerative or surgical methods offer better outcomes for patients. This double-blind, randomized clinical study involved 32 patients who were randomized into two groups. The study group (n = 16) received a novel regenerative treatment which was a standardized nanosurgery and bioengineering treatment protocol that included modified platelet-rich plasma using human cell memory intake, while the control group (n = 16) was treated with a non-standardized approach involving platelet-rich plasma and hyaluronic acid injections under ultrasound guidance without a systematized plan for orthobiologic delivery. After treatment, the mean score changes in the Visual Analog Scale, The Western Ontario and McMaster Universities Osteoarthritis Index, and the Lysholm knee scoring were significantly greater in the study group compared with the control group. These findings suggest that the novel nanosurgery and bioengineering treatment method is repeatable, objective, well-documented, and highly effective in treating meniscal tears. It offers a standardized approach that ensures rapid recovery for patients, presenting a significant advantage over less structured treatments. This study supports the use of structured regenerative protocols in clinical settings for meniscal injuries. Clinical trial registration: ISRCTN15642019

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Nanosurgery and bioengineered structural regenerative protocols for the treatment of human knee meniscal tears: a double-blind randomized controlled study of a novel regenerative method

Wasilczyk,

Wasilczyk

2024

Regenerative Medicine Reports

View full text Add to dashboard Cite

show abstract

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Digoxin and its Na+/K+-ATPase-targeted actions on cardiovascular diseases and cancer

Cited by 1 publication

References 123 publications

Nanosurgery and bioengineered structural regenerative protocols for the treatment of human knee meniscal tears: a double-blind randomized controlled study of a novel regenerative method

Nanosurgery and bioengineered structural regenerative protocols for the treatment of human knee meniscal tears: a double-blind randomized controlled study of a novel regenerative method

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