Digoxin Degradation in Acidic Dissolution Medium

Sonobe, Takashi; Hasumi, Shunji; Yoshino, Takashi; Kobayashi, Yoichi; Kawata, Hiroitsu; Nagai, Tsuneji

doi:10.1002/jps.2600690412

Cited by 20 publications

(5 citation statements)

References 22 publications

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“…For dihydrodigoxigenin, the reported cross-reactivity for the FPIA method (91%) was considerably greater than that reported for RIA methods (Gault et al 1982). The FPIA method requires serum proteins to be precipitated with 5-sulphosalicylic acid (Skogen et al 1987) which has been suggested to result in the transformation of digoxin and its metabolites to digoxigenin and/or dihydrodigoxigenin (Sonobe et al 1980). It was therefore not surprising that the metabolites were not differentiated from the drug itself using this procedure.…”

Section: Discussionmentioning

confidence: 80%

Comparison of digoxin analysis by high-performance liquid chromatography/post-column derivatization and fluorescence polarization immunoassay

Embree

McErlane

1990

Xenobiotica

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1. This study compared the analysis of digoxin using a high-performance liquid chromatographic post-column derivatization (HPLC-PC) assay and the TDx fluorescence polarization immunoassay (FPIA). 2. Serum obtained from 15 digitalized patients showed higher mean digoxin levels with the FPIA method as compared to the HPLC-PC procedure such that the mean HPLC-PC/FPIA ratio was 0.91 +/- 0.14 (mean +/- SD). Demonstrated cross-reactivity of digoxin metabolites with the FPIA is probably responsible for this observation. 3. Cross-reactivity of the immunoassay towards endogenous material present in serum samples from certain patient groups was an even greater problem, with apparent 'digoxin' serum concentrations in untreated hepatic failure patients being within the therapeutic range for digoxin. 4. The HPLC-PC method did not suffer from such interference and would therefore provide more accurate values for patients where high levels of interference could contribute to false digoxin levels.

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Section: Discussionmentioning

confidence: 80%

Comparison of digoxin analysis by high-performance liquid chromatography/post-column derivatization and fluorescence polarization immunoassay

Embree

McErlane

1990

Xenobiotica

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“…The activation energy and degradation rates were determined at various temperatures. Digoxin is known as very stable when kept in dark and well-closed containers, but it undergoes acid catalysed hydrolysis in water solutions [11,12]. The degradation products of digoxin hydrolysis are digoxigenin-bisdigitoxoside, digoxigenin-monotoxoside and digoxigenin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of photochemical degradation of digoxin by Na,K-ATPase assay

Vasić

Černigoj

Krinulović

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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“…Depending on analytical method used, it can be underestimated or overestimated. It has been reported in the literature that some of the drugs could be degraded during the dissolution study [9,11,12,14,16,21]. It is essential to know the amount of drug released and the amount of drug degraded during the dissolution study in the development of suitable formulation for the degrading drug and subsequent quality control of the developed product.…”

Section: Introductionmentioning

confidence: 99%

“…However, it is very difficult to measure the amount of degradation product accurately. Several mathematical approaches have been made to describe simultaneous dissolution and degradation [7,21].…”

Section: Introductionmentioning

confidence: 99%

An Appropriate Inflow Model for Simultaneous Dissolution and Degradation

Lee¹,

Kang²,

Choi³

2009

Honam Mathematical Journal

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Abstract. Based on the observed data for Clarithromycin released, three commonly used inflow models: the power, the exponential, and the logarithmic models are considered. Among them, the power model is used most in practice for simplicity. Using the numerical parameter estimation techniques, the parameters appeared in the model equations are estimated. Through the numerical estimation results using the several experimental data sets, the exponential model turns out to be best among the three models. More specifically, the sum of squares of absolute errors and the sum of squares of relative errors for the exponential model are reduced by 80-95 % for the experimental data sets and 60-90 % for the noise added data sets compared with those for the power and logarithmic models. A typical experimental data set is used in this paper to show the estimation method and its numerical results. The proposed numerical method and its algorithm are designed for estimating the parameters appeared in the model differential equations for which the exact form of the solution is unknown in general. The methodology developed can be applied to more general cases such as the nonlinear ordinary differential equations or the partial differential equations.

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Digoxin Degradation in Acidic Dissolution Medium

Cited by 20 publications

References 22 publications

Comparison of digoxin analysis by high-performance liquid chromatography/post-column derivatization and fluorescence polarization immunoassay

Comparison of digoxin analysis by high-performance liquid chromatography/post-column derivatization and fluorescence polarization immunoassay

Evaluation of photochemical degradation of digoxin by Na,K-ATPase assay

An Appropriate Inflow Model for Simultaneous Dissolution and Degradation

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