Digoxin Toxicity

Lecointre, K.; Pisante, L.; Fauvelle, F.; Mazouz, S. El

doi:10.2165/00044011-200121030-00009

Cited by 9 publications

(1 citation statement)

References 20 publications

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“…Female gender, hypertension, and age may worsen the prognosis. Furthermore, digoxin half-life (range 36–51 hours) may be prolonged in overdose (72–94 hours) [5, 9]. In the case we are reporting, digoxin absorption was reduced by the extravascular leakage at the site of injection.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture

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Ciccaglioni

et al. 2014

Case Reports in Psychiatry

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Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis. Arrhythmias caused by digitalis glycosides are characterized by an increased automaticity coupled with concomitant conduction delay. Bidirectional tachycardia is pathognomonic of digoxin intoxication, but it is rarely observed. An 83-year-old woman was admitted to the Emergency Department after self-administration of 5 mg of digoxin i.v. for suicidal purpose. Her digoxin serum concentration was 17.4 ng/mL. The patient developed a bidirectional tachycardia and the Poison Control Center of the hospital provided digoxin immune fab. Bidirectional tachycardia quickly reversed and the patient remained stable throughout the hospital stay. This case shows that a multiple disciplinary approach, involving cardiologists and toxicologists, is essential for the management of digoxin intoxication. The optimal treatment of this rare event depends on the clinical conditions and on the serum drug concentration of the patient. Digoxin immune fab represents a safe, effective, and specific method for rapidly reversing digitalis cardiotoxicity and should be started as soon as the diagnosis is defined.

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Section: Discussionmentioning

confidence: 99%

Bidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture

Sabatini

Truscelli

Ciccaglioni

et al. 2014

Case Reports in Psychiatry

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2001

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Cardiac glycosides

2006

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions

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Digoxin Toxicity

Abstract: Digoxin concentrations were higher in patients with toxicity. Older age enhanced the risk of digoxin toxicity. Monitoring digoxin concentrations may help to confirm suspected digitalis toxicity.

Cited by 9 publications

References 20 publications

Bidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture

Bidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture

Current Awareness

Cardiac glycosides

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