Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling

Wang, Dongsheng; Zhong, Bei; Liu, Yu; Liu, Xiaodong

doi:10.3892/ol.2017.7502

Cited by 20 publications

(18 citation statements)

References 28 publications

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“…40 Furthermore, sustained induction of the JAK2/STAT3 pathway is highly correlated to tumorigenesis, proliferation, apoptosis and metastasis of tumors, including CC. 41 While PTK6 overexpression might induce the expression of STAT3 and proliferation of breast cancer cells. 42 In addition, miR-214 modulated CC procession through c-Met sialylation via the JAK2/STAT3 pathway.…”

Section: Discussionmentioning

confidence: 99%

<p>SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner</p>

Li¹,

Wan²,

Su³

et al. 2020

CMAR

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Serum response factor (SRF), a sequence-specific transcription factor, is closely related to metastasis of gastric cancer, a digestive tract cancer. Herein, we probed the effect of SRF on metastasis and progression of colon cancer (CC), another digestive tract disorder, and the detailed mechanism. Methods: Microarray analysis was conducted on tumor and adjacent tissues to filter differentially expressed miRNA, followed by RT-qPCR validation in CC cell lines. The transcription factor and the target gene of microRNA-214 (miR-214) were predicted, and their binding relationships were tested by luciferase reporter assays and ChIP assays. Subsequently, SRF and protein tyrosine kinase 6 (PTK6) expression in CC patients and cells was evaluated by RT-qPCR, while JAK2 and STAT3 expression in cells by Western blot analysis. To further explore functions of miR-214, PTK6 and SRF on CC, CC cells were delivered with si-PTK6, miR-214 mimic and/or SRF overexpression. Results: miR-214 expressed poorly in CC tissues and cell lines, which related to advanced TNM staging and survival. miR-214 mimic inhibited proliferation, migration, invasion, xenograft tumor growth and metastasis of CC cells. SRF, overexpressed in CC samples and cells, suppressed the transcription of miR-214. Meanwhile, SRF upregulation counteracted the inhibitory role of miR-214 mimic in CC cell growth. miR-214 negatively regulated PTK6 expression to impair the JAK2/STAT3 pathway activation, thereby halting CC cell proliferation, migration, invasion, xenograft tumor growth and metastasis. Conclusion: Altogether, miR-214 may perform as a tumor suppressor in CC, and the SRF/ miR-214/PTK6/JAK2/STAT3 axis could be applied as a biomarker and potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

<p>SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner</p>

Li¹,

Wan²,

Su³

et al. 2020

CMAR

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“…Dihydroartemisinin has been found to have potent cytotoxic and proapoptotic activity by suppressing activated JAK2/STAT3 signals. It also suppressed downstream targeted proteins in the human tongue (Cal-27), colon (HCT-116), liver (HepG2) as well as head and neck (FaDu) carcinoma cell lines [217,218].…”

Section: Dihydroartemisininmentioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

144

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Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, the therapeutic potency of phytoconstituents as inhibitors of JAK/STAT signaling against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress the JAK/STAT pathway in order to impede cancer cell growth. Various databases, such as PubMed, ScienceDirect, Web of Science, SpringerLink, Scopus, and Google Scholar, were searched using relevant keywords. Once the authors were in agreement regarding the suitability of a study, a full-length form of the relevant article was obtained, and the information was gathered and cited. All the complete articles that were incorporated after the literature collection rejection criteria were applied were perused in-depth and material was extracted based on the importance, relevance, and advancement of the apprehending of the JAK/STAT pathway and their relation to phytochemicals. Based on the critical and comprehensive analysis of literature presented in this review, phytochemicals from diverse plant origins exert therapeutic and cancer preventive effects, at least in part, through regulation of the JAK/STAT pathway. Nevertheless, more preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK/STAT signaling to achieve efficient cancer control and treatment.

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“…Artemisinin exhibited the ability for selectively inhibiting cancer cells but only minimal cytotoxicity to normal cells (Li X. et al, 2018). Most notably, DHA, a derivative of artemisinin with better water solubility, has shown potent effects on cell growth inhibition and apoptosis induction by significantly inhibiting Jak2/STAT3 signaling activation and downstream target proteins in human head and neck cancer FaDu, liver cancer Hep-G2, colon cancer HCT-116, and tongue cancer Cal-27 cells (Jia et al, 2016; Wang D. et al, 2017). Moreover, a study showed that DHA at the concentration of 20 µM induced transient activation of JNK in human umbilical vein endothelial cells (Dong et al, 2016).…”

Section: Anticancer Tcms Through Targeting Jak-stat3 Signal Pathwaymentioning

confidence: 99%

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines

Lai

Zhang

et al. 2019

Front. Pharmacol.

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Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional Chinese medicines (TCMs) by targeting the cellular apoptotic pathway of cancer cells and shown clinically beneficial effects in cancer therapy. This review aims to provide a comprehensive discussion for the role, pharmacology, related biology, and possible mechanism(s) of a number of important anticancer TCMs and their derivatives mainly targeting the cellular apoptotic pathway. It may have important clinical implications in cancer therapy.

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Dihydroartemisinin increases apoptosis of colon cancer cells through targeting Janus kinase 2/signal transducer and activator of transcription 3 signaling

Cited by 20 publications

References 28 publications

<p>SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner</p>

<p>SRF Potentiates Colon Cancer Metastasis and Progression in a microRNA-214/PTK6-Dependent Manner</p>

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines

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