Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis

Bélanger, Audrey; Grenier, Alexe; Simard, François; Gendreau, Isabelle; Pichette, André; Legault, Jean; Pouliot, Roxane

doi:10.3390/ijms21010256

Cited by 25 publications

(28 citation statements)

References 55 publications

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“…RAW 264.7 cells are a well-established model for predicting the anti-inflammatory potential of drugs, since they easily increase NO production upon stimulation through incremental iNOS expression. This model has been widely used in the context of psoriasis [43,44] and was adopted in this study.…”

Section: Anti-inflammatory Potentialmentioning

confidence: 99%

“…HPLC-PDA recorded at 450 nm. Unidentified carotenoids (3, 5-8, 10-13, 15, 23, 25, 28, 31, 40-43), β-carotene oxygenated derivatives (9, 17, 34, 35), Lutein derivatives(14,16,19,22,24), Echinenone derivatives(30), Chlorophyll a derivatives(32,33,38), Unidentified Chlorophylls(44)(45)(46)(47), Zeaxanthin(21), Canthaxanthin(26), Chlorophyll a(36), Echinenone(37), all-trans β-Carotene (48), α-Carotene derivative (49), 13-cis-β-Carotene(50).…”

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confidence: 99%

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Carotenoids from Cyanobacteria: A Biotechnological Approach for the Topical Treatment of Psoriasis

2020

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In this study, five cyanobacteria strains (Alkalinema aff. pantanalense LEGE15481, Cyanobium gracile LEGE12431, Nodosilinea (Leptolyngbya) antarctica LEGE13457, Cuspidothrix issatschenkoi LEGE03282 and Leptolyngbya-like sp. LEGE13412) from the Blue Biotechnology and Ecotoxicology Culture Collection (LEGE CC) of CIIMAR were explored for their biotechnological potential in the treatment of psoriasis. Different extracts were characterized for their pigment profile by HPLC-PDA. The antioxidant potential of the extracts was assessed against the superoxide anion radical (O2•-). Their anti-inflammatory and antiproliferative potential was assessed in vitro using the macrophages RAW 264.7 and the human keratinocytes HaCaT as cell-line models, respectively. Terrestrial and freshwater strains presented the highest carotenoid content (33193−63926 μg/g dry extract), with all-trans-β-carotene, zeaxanthin, echinenone and lutein derivatives being the most abundant carotenoids. Acetone was the most effective solvent for pigment extraction. The acetone extracts presented the lowest IC50 values (0.29−0.38 mg dry extract/mL) regarding O2•- scavenging, and revealed anti-inflammatory potential, with N. antarctica LEGE13457, A. pantanalense LEGE15481 and Leptolyngbya-like sp. LEGE13412 reducing the nitric oxide (NO) in RAW 264.7 cell culture medium in about 25% (p < 0.05). With the exception of A. pantanalense LEGE15481, all the extracts significantly reduced keratinocyte proliferation (p < 0.05), demonstrating a selective toxicity among the different cell lines. Overall, Leptolyngbya-like sp. LEGE13412 and N. antarctica LEGE13457 seem promising for further exploitation in the framework of psoriasis, due to their antioxidant, anti-inflammatory and antiproliferative potential.

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Section: Anti-inflammatory Potentialmentioning

confidence: 99%

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confidence: 99%

Carotenoids from Cyanobacteria: A Biotechnological Approach for the Topical Treatment of Psoriasis

2020

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“…The cited authors demonstrated that positive effects could be obtained with as little as 50 μg of astilbin. The use of antioxidative balsacones isolated from balsam poplar ( Populus balsamifera L) on human fibroblasts harvested from fragments of psoriatic skin reduced the cell growth rate and stabilised the expression of cells in involucrin and loricrin more effectively than methotrexate [ 150 ]. Local application of propolis, due to its content of flavonoids, helps to improve the condition of psoriatic skin by suppressing the activity of macrophages and production of ROS [ 151 ].…”

Section: External Application Of Antioxidants In Psoriasismentioning

confidence: 99%

Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

2020

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Psoriasis is a common, chronic, hyperproliferative, inflammatory skin disease occurring in most ethnic groups in the world. The disease is hereditary but the process of its inheritance is complex and still not fully understood. At the same time, it has been observed that psoriatic lesions may be triggered by certain prooxidative external factors: using narcotics, smoking, drinking alcohol, physical and mental stress, as well as bacterial infections and injury. Since the main physiological marker of psoriasis relates to disorders in the organism’s antioxidative system, it is necessary to develop a well-balanced combination of pharmaceuticals and dietary antioxidants to facilitate the effective treatment and/or prevention of the disease. The dietary sources of antioxidants must be adequate for chronic use regardless of the patient’s age and be easily available, e.g., as ingredients of regular food or dietary supplements. Diet manipulation is a promising therapeutic approach in the context of modulating the incidence of chronic diseases. Another potentially viable method entails the use of nutrigenomics, which guarantees a multiaspectual approach to the problem, including, in particular, analyses of the genetic profiles of psoriasis patients with the view to more accurately targeting key problems. The present paper pertains to the significance of redox equilibrium in the context of psoriasis. Based on information published in worldwide literature over the last decade, the impact of dietary exogenous antioxidants on the course of this chronic disease was analysed.

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“…Many parts of this tree, such as the buds, leaves, and bark, can be used as active ingredients for the pharmaceutical industry. In European traditional medicine, black poplar buds were generally recommended as a remedy in respiratory infections (cough, laryngitis, bronchitis, sore throat) and also in the treatment of dermatological problems (psoriasis), rheumatic inflammations, and hemorrhoids [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Inorganic Element Determination of Romanian Populus nigra L. Buds Extract and In Vitro Antiproliferative and Pro-Apoptotic Evaluation on A549 Human Lung Cancer Cell Line

et al. 2021

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Populus nigra L. is a plant from Salicaceae family, native in Europe. Many parts of this tree can be used as active ingredients, but the most valuable are the buds. In recent years, a growing number of studies reported their activity in the development of a wide range of pharmacological activities including diabetes, cardiovascular diseases, and cancer. The aim of this study was to determine the phytochemical composition and to evaluate the inorganic elements’ concentration as well as the in vitro antiproliferative and pro-apoptotic potential of a Populus nigra L. buds extract collected from Timișoara (Romania) against A549 human lung cancer cell line. Populus nigra L. bud extract was found to contain twelve different phenolic compounds. The inorganic elements concentrations were below the limit of detection for Co, Pb, and As, whereas Cu = 6.66 µg/g; Cr = 0.79 µg/g; Ni = 3.28 µg/g; Fe = 39.00 µg/g; Zn = 14.84 µg/g; Mn = 0.59 µg/g; Al = 2109.87 µg/g; and Cd = 0.019 µg/g. The extract was tested for the in vitro antiproliferative and pro-apoptotic potential on A549 human lung cancer cell line using different concentrations, namely 10, 25, 50, 75, 100, and 150 μg/mL. Results have shown that poplar bud extract induced a significant decrease of tumor cell viability in a dose-dependent manner with an IC50 = 72.49 μg/mL and blocked the cells in the G0/G1 phase of the cell cycle. Phenomena of early apoptosis (from 1.34 ± 0.33% control cells to 2.68 ± 0.62% at 150 µg/mL) and late apoptosis (from 1.43 ± 0.14% control cells to 5.15 ± 1.02% at 150 µg/mL) were detected by Annexin V-PI double staining. Poplar bud extract can be regarded as a promising candidate for future studies involving lung cancer.

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Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis

Cited by 25 publications

References 55 publications

Carotenoids from Cyanobacteria: A Biotechnological Approach for the Topical Treatment of Psoriasis

Carotenoids from Cyanobacteria: A Biotechnological Approach for the Topical Treatment of Psoriasis

Importance of Redox Equilibrium in the Pathogenesis of Psoriasis—Impact of Antioxidant-Rich Diet

Inorganic Element Determination of Romanian Populus nigra L. Buds Extract and In Vitro Antiproliferative and Pro-Apoptotic Evaluation on A549 Human Lung Cancer Cell Line

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