Dihydromyricetin is a new inhibitor of influenza polymerase PB2 subunit and influenza-induced inflammation

Tian, Yuanxin; Sang, Huiting; Liu, Miaomiao; Chen, Fangzhao; Huang, Yingna; Li, Lin; Liu, Shuwen; Yang, Jie

doi:10.1016/j.micinf.2020.05.021

Cited by 14 publications

(9 citation statements)

References 27 publications

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“…Other disorders in which DMY appeared functional included human melanoma [116] and hypertrophic scar [117]. DMY also exhibited anti‐viral and anti‐bacterial activities, including anti‐influenza A virus [118], anti‐spoilage bacteria (mainly P. antarctica) [119] and anti‐Staphylococcus aureus [120].…”

Section: Pharmacological Effects and Actions Mechanisms Of Dmymentioning

confidence: 99%

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

Zhang

Caprioli²,

Hussain

et al. 2021

eFood

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Natural bioactive compounds present a better alternative to prevent and treat chronic diseases owing to their lower toxicity and abundant resources. (+)-Dihydromyricetin (DMY) is a flavanonol, possessing numerous interesting bioactivities with abundant resources. This review provides a comprehensive overview of the recent advances in DMY natural resources, stereoisomerism, physicochemical properties, extraction, biosynthesis, pharmacokinetics, and biotransformation. Stereoisomerism of DMY should be considered for better indication of its efficacy. Biotechnological approach presents a potential tool for the production of DMY using microbial cell factories. DMY high instability is related to its powerful antioxidant capacity due to pyrogallol moiety in ring B, and whether preparation of other analogues could demonstrate improved properties. DMY demonstrates poor bioavailability based on its low solubility and permeability with several attempts to improve its pharmacokinetics and efficacy. DMY possesses various pharmacological effects, which have been proven by many in vitro and in vivo experiments, while clinical trials are rather scarce, with underlying action mechanisms remaining unclear. Consequently, to maximize the usefulness of DMY in nutraceuticals, improvement in bioavailability, and better understanding of its actions mechanisms and drug interactions ought to be examined in the future along with more clinical evidence.

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Section: Pharmacological Effects and Actions Mechanisms Of Dmymentioning

confidence: 99%

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

Zhang

Caprioli²,

Hussain

et al. 2021

eFood

View full text Add to dashboard Cite

show abstract

“…The antiviral effects of some flavonoid aglycones and their derivatives have been investigated [31,32] and have the potential to inhibit each viral growth stage [33][34][35]. Naringenin has been reported to be effective against various viruses [36,37], but there are few reports on its effectiveness against influenza viruses.…”

Section: Discussionmentioning

confidence: 99%

Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones

et al. 2022

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Vaccines and antiviral drugs are widely used to treat influenza infection. However, they cannot rapidly respond to drug-resistant viruses. Therefore, new anti-influenza virus strategies are required. Naringenin is a flavonoid with potential for new antiviral strategies. In this study, we evaluated the antiviral effects of naringenin derivatives and examined the relationship between their cellular uptake and antiviral effects. Madin–Darby canine kidney (MDCK) cells were infected with the A/PR/8/34 strain and exposed to the compound-containing medium for 24 h. The amount of virus in the supernatant was calculated using focus-forming reduction assay. Antiviral activity was evaluated using IC50 and CC50 values. Cells were exposed to a constant concentration of naringenin or prenylated naringenin, and intracellular uptake and distribution were evaluated using a fluorescence microscope. Prenylated naringenin showed strong anti-influenza virus effects, and the amount of intracellular uptake was revealed by the strong intracellular fluorescence. In addition, intracellular distribution differed depending on the position of the prenyl group. The steric factor of naringenin is deeply involved in influenza A virus activity, and prenyl groups are desirable. Furthermore, the prenyl group affects cellular affinity, and the uptake mechanism differs depending on its position. These results provide important information on antiviral strategies.

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“…Nonetheless, RNA-dependent RNA-polymerase remains an attractive target for antiviral development due to its critical roles in virus replication and the high degree of sequence conservation ( Stevaert and Naesens, 2016 ). Therefore, the search for new polymerase inhibitors is likely to continue, including those targeting the cap-binding domain of PB2 ( Chen et al, 2020 ; Tian et al, 2020 ). Our study reinforced the notion that naturally occurring resistance to pimodivir is rare in both seasonal and non-seasonal influenza A viruses.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir

et al. 2021

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Dihydromyricetin is a new inhibitor of influenza polymerase PB2 subunit and influenza-induced inflammation

Cited by 14 publications

References 27 publications

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

Effect of Structural Differences in Naringenin, Prenylated Naringenin, and Their Derivatives on the Anti-Influenza Virus Activity and Cellular Uptake of Their Flavanones

Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir

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