Dihydroörotic Acid

Abstract

The agreement here with the analytical results is substantially as good as that given by the first structure, and the molecular weight found is somewhat closer to the calculated value in this case.The analysis of the solid polymeric residue left after heating the solid reaction products under reduced pressure, to sublime away any ammonium chloride, while not as conclusive as that presented for the silazanes, led to results approaching the requirements of the simple empirical formula, (Cl-Si^N)*. One such sample, for example, gave the following data:

Pyrimidine Metabolism in Man. I. The Biosynthesis of Orotic Acid*†

“…dl-Dihydroorotate-C14 (DHO-C14) was synthesized by the catalytic hydrogenation of orotate-C'4 (labeled in carbon 6) using a rhodiumalumina catalyst (6) and measured as described by Yates and Pardee (7). Nonlabeled l-dihydroorotate was synthesized by the method of Miller, Gordon and Englehardt (8). dl-5-Carboxymethylhydantoin-C14 (5-CMH-C") labeled in the carboxyl group was prepared from the above dl-DHO-C1' (3) and measured as described by Lieberman and Kornberg (9).…”

Chemie der α‐Aminonitrile 1. Mitteilung Einleitung und Wege zu Uroporphyrinogen‐octanitrilen

“…'H-NMR (100 MHz): 1,00, 1,07,1,09 (3s,6 CH,); 15,2,95 (2m,6 CH2);7,97 (s,2 NH). ',C-NMR (75,47 MHz): 9,70,16,35,16.50 (34,6 CH,);28,86,(s,2 C=O). MS: 498 (l), 497 (S), 496 (15, Ad+'), 83 (100).…”

“…s,2 NH). "C-NMR (75,47 MHz): 9,60,9,66 (24,2 CH,);16,39 (4,2 CH,);16,52,16.61 (24,2 CH,);28,89,29,06,29,50,29,76,29,98,CN);168,14,169,80 (2s,2 C02);177,39,177,82 (2s,2 C=O). MS: 497 (17), 496 (49, M"), 83 (100).…”

“…6.3. Ringoflnung von tic-20 zu rac-GIutamindinitril ( 29,00,29,05,30,37(3t,6CH2);54,64,55,48,56,11 (3~,6C); 91,72(~,115,53(~,2CN); 168,36(~,2C02); 28,93,30,34(3t,6CH2);54,75,55,48,56,16(3s,6C); 91,63(s,2C-O); 115,86(~,2CN);.l68,34(~,2C02); 177,88 30,68(6t,6CH2);53,78,54,29,54,68,54,89(4s,4C);55,40(s,2C); 91,76,91,91(2s,2C-O); 115,72, 116, Fig.6): 3670w, 3405s, 3340m, 3020s,2940m, 2867iv, 2250s, 2235 (sh), 1623m (br. ), 1446s, 1424s, 1368w, 1310m, Fig.…”

“…-Am Ausgangspunkt unserer Untersuchungen uber die Chemie von 3 hat uns vor allem der strukturelle Zusammenhang dieser Verbindung mit Nitril-Formen von proteinogenen Aminosauren beschaftigt. Vom (scheinbar")) offensichtlichen Zusammenhang mit den Nitril-Formen des Alanins, Serins, Glycins, Cysteins und Asparagins abgesehen, interessierte dabei vorab der Zusammenhang der Struktur von 3 mit derjenigen der Dinitril-Form des Glutamins; die Glutaminsaure gehort zu den vier proteinogenen a-Aminosauren des ursprunglichen Millerschen Experiments [28]. Wie Schema I I erlautert, korrelieren die Strukturen von 3 und Glutamindinitril via den Reaktionstyp einer Schwanz/ Schwanz-Dimerisierung von 3.…”