Dihydroquercetin: More than just an impurity?

Weidmann, Anita Elaine

doi:10.1016/j.ejphar.2012.03.035

Cited by 169 publications

(141 citation statements)

References 91 publications

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“…В связи с тем, что окисленные ЛНП участвуют в атеросклеротическом изменении стенок сосудов, наблюдаемое усиление антиоксидантных свойств ДГК и РЕС в составе фосфолипидных наночастиц можно рассматривать как увеличение антиатерогенных свойств исследуемых полифенолов [3,4].…”

Section: результаты и обсуждениеunclassified

“…дигидрокверцетина (ДГК). Например, доказана их способность повышать экспрессию эндотелиальной NO-синтазы (eNOS) [3,5]. РЕС регулирует тонус сосудов, влияя на синтез высокоактивного вазоконстриктора эндотелина-1, а также индуцирует экспрессию фосфатидилинозит-3-киназы [5].…”

unclassified

“…Участие РЕС и ДГК в регуляции множества метаболических процессов составляет основу лечебно-профилактического действия при терапии различных патологий [2][3][4]. Многочисленные данные о биологической активности РЕС и ДГК объясняют их активное использование в составе различных лечебно-профилактических препаратов [4].…”

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Influence of resveratrol and dihydroquercetin inclusion into phospholipid nanopatricles on their bioavailability and specific activity

Guseva

Khudoklinova²,

Medvedeva

et al. 2015

BIOMED KHIM

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The effects of natural polyphenols, resveratrol (RES) and dihydroquercetin (DHQ), included in phospholipid nanoparticles, have been compared with free substances of RES and DHQ in in vitro and in vivo experiments. Preincubation of healthy donor plasma low density lipoproteins (LDL) with RES or DHQ included in phospholipid nanoparticles caused a more pronounced decrease in Cu2+ induced lipid oxidation compared with the free substances, and reduced the formation of lipid peroxides products. Bioavailabilities of RES and DHQ in phospholipid formulations after oral administration in rats were increased by 1.5-2 times. In an acute hypoxia model in mice prophylactic two-week administration of RES or DHQ phospholipid formulations resulted in 25% increase in survival and 1.5-fold increase in catalase activity in brain homogenates compared to free substances. Using the model of endothelial dysfunction in rats induced by L-NAME it was shown, that RES markedly attenuated the inhibition effect of L-NAME on NO synthesis. RES in phospholipid nanoparticles had the same action at a dose 10 times lower compared to free RES. Load test with resistance (clamping of the ascending aorta for 30 sec) showed that phospholipid formulation of RES possessed more pronounced protective effect due to the stimulation of endothelial NO-synthase.

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Section: результаты и обсуждениеunclassified

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Influence of resveratrol and dihydroquercetin inclusion into phospholipid nanopatricles on their bioavailability and specific activity

Guseva

Khudoklinova²,

Medvedeva

et al. 2015

BIOMED KHIM

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“…Studies have demonstrated that quercetin can modestly reduce weight and regulate the expression of genes related to in vitro adipogenesis [103,104] . Quercetin reduces inflammatory cytokine levels and improves lipid peroxidation and insulin resistance in animal models of NAFLD, and its beneficial effects are dose dependent [103,105] . There is no clinical trial evaluating its effects on patients with NAFLD.…”

Section: Insulin Sensitizers and Lipid Lowering Agentsmentioning

confidence: 99%

“…Quercetine: Quercetin, a plantderived bioflavonoid, has been reported to provide an improved health status to its consumers, particularly with regard to obesity and diabetes [103] . Studies have demonstrated that quercetin can modestly reduce weight and regulate the expression of genes related to in vitro adipogenesis [103,104] .…”

Section: Insulin Sensitizers and Lipid Lowering Agentsmentioning

confidence: 99%

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

Eslamparast¹,

Eghtesad²,

Poustchi³

et al. 2014

WJH

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Prokaryotic and Eukaryotic Aryl Sulfotransferases: Sulfation of Quercetin and Its Derivatives

et al. 2015

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Two types of sulfotransferases, namely recombinant rat liver aryl sulfotransferase AstIV and bacterial aryl sulfotransferase from Desulfitobacterium hafniense, were used for the sulfation of quercetin, its glycosylated derivatives (isoquercitrin and rutin), and dihydroquercetin ((+)‐taxifolin). The rat liver enzyme was able to sulfate only quercetin and taxifolin, whereas the quercetin glycosides remained intact. The D. hafniense enzyme sulfated isoquercitrin and rutin selectively at the C‐4′ position of the catechol moiety with very good yields. Taxifolin was sulfated at the C‐4′ position and a minor amount of the C‐3′ isomer was formed. Sulfation of quercetin proceeded preferentially at the C‐3′ position, but a lower proportion of the C‐4′ isomer was formed as well. A detailed analysis of the kinetics of this reaction is provided and a full structural analysis of all products is presented.

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Dihydroquercetin: More than just an impurity?

Cited by 169 publications

References 91 publications

Influence of resveratrol and dihydroquercetin inclusion into phospholipid nanopatricles on their bioavailability and specific activity

Influence of resveratrol and dihydroquercetin inclusion into phospholipid nanopatricles on their bioavailability and specific activity

Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

Prokaryotic and Eukaryotic Aryl Sulfotransferases: Sulfation of Quercetin and Its Derivatives

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