Dihydroquercetin, the Bioactive Substance, to Be Used Against Pathogenic Microorganisms as an Alternative to Antibiotics

Артемьева, О А; Переселкова, Д А; Fomichev, Yu. P.

doi:10.15389/agrobiology.2015.4.513eng

Cited by 15 publications

(15 citation statements)

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“…Antibiotics play key role in the treatment of diseases, helping human beings to reduce the mortality rate of various infections, and significantly improving people's quality of life and life expectancy [92]. Moreover, antibiotics have been widely used as adjuvant drugs in the process of surgical treatment, radiotherapy, chemotherapy and immunotherapy of cancers due to their anti-infection and anticancer effects [93].…”

Section: Future Directionsmentioning

confidence: 99%

Antibiotics for cancer treatment: A double-edged sword

et al. 2020

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Various antibiotics have been used in the treatment of cancers, via their anti-proliferative, pro-apoptotic and anti-epithelial-mesenchymal-transition (EMT) capabilities. However, increasingly studies have indicated that antibiotics may also induce cancer generation by disrupting intestinal microbiota, which further promotes chronic inflammation, alters normal tissue metabolism, leads to genotoxicity and weakens the immune response to bacterial malnutrition, thereby adversely impacting cancer treatment. Despite the advent of high-throughput sequencing technology in recent years, the potential adverse effects of antibiotics on cancer treatments via causing microbial imbalance has been largely ignored. In this review, we discuss the double-edged sword of antibiotics in the field of cancer treatments, explore their potential mechanisms and provide solutions to reduce the potential negative effects of antibiotics.

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Section: Future Directionsmentioning

confidence: 99%

Antibiotics for cancer treatment: A double-edged sword

et al. 2020

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“…Effectiveness of clinical mastitis treatment depends on immune resistance of an animal, infection duration and bacterial genotypes of a causative agent [26]. For selection of a treatment regimen and mastitis prevention measures in cows it is important to study the mechanism of antibiotic resistance and spreading of infection caused by S. aureus [27][28][29][30].…”

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confidence: 99%

ANTIBIOTIC-RESISTANCE PROFILE OF Staphylococcus aureus STRAINS ISOLATED FROM MILK OF HIGH YIELD COWS IN CENTRAL RUSSIA

Артемьева¹,

Nikanova²,

Kotkovskaya³

et al. 2016

S-h. biol.

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A b s t r a c tThe development of microbial resistance to antibiotics determines the effectiveness of the veterinary measures. The study and monitoring, well-designed treatment schemes are those measures that help to reduce the risk of spread of pathogenic and conditional-pathogenic microorganisms. One of the problems in the dairy farming is mastitis of high producing cows which is mainly caused by Staphylococcus aureus. Here we first report findings on the development of resistance in S. aureus strains isolated from milk of clinically healthy dairy cows during treatment with antibiotics of different classes. The study was carried out using high yield holsteinized black-and-white cows (n = 1321, Kaluga region, 2016) which were vaccinated twice with anti-mastitis drug Mastivak («Ovejero», Spain). Milk was sampled during the lactation period individually from each cow. For the species identification of S. aureus isolates we used the following criteria: (i) morphology and microscopy of the colonies grown on the Baird Parker Agar medium («HiMedia Laboratories Pvt., Ltd», India); (ii) the presence of hemolysis zones on the Azide Blood Agar Pronadisa medium («Conda», Spain) supplemented with 5 % defibrinated sheep blood; (iii) a coagulation of dry citrated rabbit plasma (CJSC «EKOlab», Russia); (iv) biochemical characterization with API 20 STAPH panel («BioMerieux», France). S. aureus ATCC 25923 was a reference strain. The sensitivity of the isolated microorganisms to ten antibiotics («Pharmacotherapy Research Center», Russia) including penicillin (PEN, 10, ED), oxacillin (OX, 10 μg), gentamicin (GN, 10 μg), erythromycin (ER, 15 μg), lincomycin (LN, 15 μg), rifampicin (RF, 5 μg), ciprofloxacin (CP, 5 μg), vancomycin (VA, 30 μg), fuzidin (FZ, 10 μg) and novobiocin (NB, 5 μg) was determined by disk diffusion method. A total of 104 strains among 155 isolates (67.1 %) showed resistance to one or more antibiotics. The majority of the strains were resistant to novobiocin (49.7 %) while the smallest part (2.6 %) exhibited resistant to vancomycin. Importantly, the antibiotic resistance to next-generation antibacterial agents (novobiocin and vancomycin) which are currently widely used in medicine should be noted. Gentamicin, rifampicin and vancomycin had the highest efficiency among the tested antibiotics (81.9 %, 86.5 % and 97.4 %, respectively). In order to evaluated the effectiveness of antibiotic treatment strategy, the cows (n = 87) with pre-detected S. aureus were divided into four groups. Gentamicin was administrated in group I (n = 26), erythromycin was administrated in group II (n = 22), rifampicin was administrated in group III (n = 12), and penicillin and amoxicillin were administrated in group IV (n = 27). The animals were considered cured when no S. aureus after the treatment. Rifampicin application was the most effective (91.7 %) whereas gentamicin showed the lowest effectiveness (53.8 %). Moreover, the number of multidrug resistant strains reached 55.6-61.5 % after the treatment comparing to 33.3-43.8 % before t...

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“…petals [11], the goji berry (Lycium barbarum) dried fruits and pu mpkin powder [12] and others have been investigated for benefiting food stability. Dihydroquercetin (DHQ) is capable of donating an electron and as such, inhibits hydroxy l rad icals [13]. DHQ is a powerfu l antioxidant that deactivates alkylpero xy l and superoxide rad icals, reduces haemolysis induced by phospholipase C and inhibits superoxide produced by xanthine o xidase [14].…”

Section: Introductionmentioning

confidence: 99%

“…DHQ is a powerfu l antioxidant that deactivates alkylpero xy l and superoxide rad icals, reduces haemolysis induced by phospholipase C and inhibits superoxide produced by xanthine o xidase [14]. Dihydroquercetin is a proven antio xidant, capillary p rotector with hepatoprotective, gastroprotective, anti-inflammatory, antisclerotic, radioprotective, anti-coagulant, anti-inflammatory properties and inhib its the LDLcholesterol o xidation in b lood serum [13]. Dihydroquercetin is often used for the prevention of o xidative stress and is well accepted as a treatment for select carcino mas, and cardiovascular and liver diseases [13].…”

Section: Introductionmentioning

confidence: 99%

“…Dihydroquercetin is a proven antio xidant, capillary p rotector with hepatoprotective, gastroprotective, anti-inflammatory, antisclerotic, radioprotective, anti-coagulant, anti-inflammatory properties and inhib its the LDLcholesterol o xidation in b lood serum [13]. Dihydroquercetin is often used for the prevention of o xidative stress and is well accepted as a treatment for select carcino mas, and cardiovascular and liver diseases [13]. DHQ's anti-radical activ ity occurs at a concentration of about 0.0001-0.00001% in the absence of mutagenic activity [10].…”

Section: Introductionmentioning

confidence: 99%

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Improving the oxidative stability of pork by antioxidant type phytonutrients

2020

Biointerface Res Appl Chem

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The objective of this study was to determine the influence of supplementations with 3.5 or 7.5 mg dihydroquercetin (experimental groups D1 and D2) or with 0.255 or 0.545 g dry distilled rose petals (experimental groups R1 and R2)/kg/d added as to pig’s combined feed on the parameters of lipolysis expressed by acid value; lipid hydroperoxides expressed by peroxide value, lipid oxidation secondary products expressed by 2-tiobarbituric acid reactive substances (TBARS), pH and L*, a*, b* colour characteristics in m. Longissimus lumborum et thoracis, m. Semimembranosus, backfat and leaf fat stored 24 h and 7d at 2±1°C, or 315 d at -18±1°C. A total of 120 pigs were randomly divided into five groups – a control (C) and four experimental (D1, D2, R1 and R2) each fed 45 d prior to harvest with shown above levels of phytonutrients enriched diets. More pronounced effects were determined (P≤0.05) at frozen storage compared to chilled storage. The oxidative and colour stabilities of chilled (2±1°C) and frozen (-18°C) pork are comparatively higher when pig’s diet was supplemented with 3.5 mg dihydroquercetin or 0.255 g dry distilled rose petals/kg/d. The conclusion was made can the supplementation of pig’s combined feed (finisher) with 3.5 mg dihydroquercetin or 0.255 g dry distilled rose petals/kg/d is a promising strategy to increase the oxidative stability of lean pork or fat and stabilized pork meat colour without deleterious changes of meat acidity.

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Dihydroquercetin, the Bioactive Substance, to Be Used Against Pathogenic Microorganisms as an Alternative to Antibiotics

Cited by 15 publications

References 9 publications

Antibiotics for cancer treatment: A double-edged sword

Antibiotics for cancer treatment: A double-edged sword

ANTIBIOTIC-RESISTANCE PROFILE OF Staphylococcus aureus STRAINS ISOLATED FROM MILK OF HIGH YIELD COWS IN CENTRAL RUSSIA

Improving the oxidative stability of pork by antioxidant type phytonutrients

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