Dihydrotestosterone inhibits murine hair growth via the androgen receptor

Naito, Akira; Satō, Takashi; Μatsumoto, Takahiro; Takeyama, Ken-ichi; Yoshino, Teruhiko; Kato, Shigeaki; Ohdera, Motoyasu

doi:10.1111/j.1365-2133.2008.08671.x

Cited by 30 publications

(21 citation statements)

References 36 publications

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“…Studies using ARKO mice have in recent years provided several new insights into the androgen-AR system. Male ARKO mice demonstrate late-onset obesity , with decreased energy expenditure and enhanced insulin sensitivity (Fan et al 2005), disordered hypothalamic leptin signaling (Fan et al 2008), high turnover osteopenia , impaired brain masculinization (Sato et al 2004), dysregulation of the pituitary glucocorticoid feedback system (Miyamoto et al 2007), enhanced hair growth (Naito et al 2008), and altered skeletal muscle strength (Chambon et al 2010). ARKO mice are thus a useful tool for investigating androgen-AR activity in classical and nonclassical target organs and may have advantages over conventional models such as gonadectomized animals or administration of AR antagonists.…”

Section: Androgen Effects On Cardiac Remodelingmentioning

confidence: 99%

Effects of androgens on cardiovascular remodeling

Ikeda

Aihara

Yoshida³

et al. 2012

Journal of Endocrinology

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Androgens, the male sex hormones, exert various biological effects on many target organs through the transcriptional effects of the nuclear androgen receptor (AR). ARs are expressed not only in classical target organs, such as the brain, genital organs, bone, and skeletal muscles, but also in the cardiovascular system. Because the female sex hormones estrogens are wellknown to protect against cardiovascular disease, sex has been considered to have a significant clinical impact on cardiovascular mortality. However, the influence of androgens on the cardiovascular system has not been fully elucidated. To clarify this issue, we analyzed the effects of administration of angiotensin II and doxorubicin, an anticancer agent, in a loading model in male wild-type and AR-deficient mice. In this review, we focus on the actions of androgens as potential targets for the prevention of cardiovascular diseases in males.

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Section: Androgen Effects On Cardiac Remodelingmentioning

confidence: 99%

Effects of androgens on cardiovascular remodeling

Ikeda

Aihara

Yoshida³

et al. 2012

Journal of Endocrinology

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“…We also used both OCT and histological measurements to investigate the effect of helium-neon (He-Ne) laser (632.8 nm) irradiation on the hair follicle growth cycle in normal and testosterone-treated mice skin. In previous studies, it has been shown that exogenous androgens can be used to impair hair growth in albino mice [16] and pigmented mice [17,18] . The objective of this study was to investigate the role of low-level laser irradiation on the hair follicle growth cycle of normal as well as testosterone-treated mice.…”

Section: Introductionmentioning

confidence: 99%

Effect of Helium-Neon Laser Irradiation on Hair Follicle Growth Cycle of Swiss Albino Mice

Shukla

Sahu²,

Verma³

et al. 2009

Skin Pharmacol Physiol

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We report the results of a study carried out to investigate the effect of helium-neon (He-Ne) laser (632.8 nm) irradiation on the hair follicle growth cycle of testosterone-treated and untreated mice. Both histology and optical coherence tomography (OCT) were used for the measurement of hair follicle length and the relative percentage of hair follicles in different growth phases. A positive correlation (R = 0.96) was observed for the lengths of hair follicles measured by both methods. Further, the ratios of the lengths of hair follicles in the anagen and catagen phases obtained by both methods were nearly the same. However, the length of the hair follicles measured by both methods differed by a factor of 1.6, with histology showing smaller lengths. He-Ne laser irradiation (at ∼1 J/cm²) of the skin of both the control and the testosterone-treated mice was observed to lead to a significant increase (p < 0.05) in % anagen, indicating stimulation of hair growth. The study also demonstrates that OCT can be used to monitor the hair follicle growth cycle, and thus hair follicle disorders or treatment efficacy during alopecia.

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“…We previously reported that DHT implantation remarkably suppressed hair regrowth after depilation. 22) As shown in Fig. 3, DHT-implanted mice treated with vehicle (Control-group) showed a remarkably retardation of hair regrowth.…”

Section: Hura Crepitans L Inhibits the Nt-4 Activation Induced By Dhmentioning

confidence: 99%

“…22) Male C57BL/6 mice (n=6) were purchased from Nihon SLC (Shizuoka, Japan) and maintained according to a protocol approved by the Animal Care and Use Committee of LION Corporation. The dorsal hair of male mice in the telogen stage (52 d postpartum) was removed with electric hair clippers and shavers, and the anagen stage was induced.…”

Section: Plasmid Construction and Luciferase Reporter Assaymentioning

confidence: 99%

Effects of Hura crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation

Uchiyama

Ishida

Tsutsui

et al. 2012

Biological & Pharmaceutical Bulletin

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Neurotrophin (NT)-4 is known to be an inducer of catagen in the hair cycle, but little is known of its role in the pathogenesis of androgenetic alopecia (AGA). We previously studied the gene expression of dermal papilla cells from AGA patients and controls and found that NT-4 was up-regulated in the AGA patients. In the present study, the etiological relationship between NT-4 and androgen, which is one of the causes of AGA, and the effect of an NT-4 inhibitor on hair growth were investigated. We established a NT-4 luciferase reporter assay system using a roughly 2-kb region upstream of the NT-4 transcriptional start site and investigated an accelerating effect of androgen on NT-4 transcription. We also screened for a NT-4 inhibitor by using the NT-4 reporter assay and evaluated the effects of NT-4 inhibitors on hair growth by using dihydrotestosterone (DHT)-implanted mice. The results show that transcriptional activity of NT-4 was accelerated by androgen, and extract of Hura crepitans L. inhibited the DHT-induced NT-4 transcriptional activation and ameliorated the retardation of hair regrowth by DHT-implanted mice. We also isolated the active ingredient in H. crepitans and found its structure to be that of 6,7-epoxy-5-hydroxyresiniferonol-14-(2,4-tetradecadienoate), i.e., daphne factor F3. These findings demonstrated that NT-4 activity accelerated by androgen might contribute to the pathogenesis of AGA and indicated that NT-4 inhibitors such as H. crepitans and daphne factor F3 might have a salutary effect on AGA.

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Dihydrotestosterone inhibits murine hair growth via the androgen receptor

Abstract: Androgens inhibit hair growth in mice, and this inhibition might be caused by androgen-androgen receptor signals.

Cited by 30 publications

References 36 publications

Effects of androgens on cardiovascular remodeling

Effects of androgens on cardiovascular remodeling

Effect of Helium-Neon Laser Irradiation on Hair Follicle Growth Cycle of Swiss Albino Mice

Effects of Hura crepitans and Its Active Ingredient, Daphne Factor F3, on Dihydrotestosterone-Induced Neurotrophin-4 Activation and Hair Retardation

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