Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy

Abstract

Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.

A Theranostic Agent Combining a Two‐Photon‐Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection

“…Best-fit parameters obtained from the fitting of the 1 HNMRD profiles to the SBM theory,i ncluding the Lipari-Szabo approach for internal flexibility. [11] The emission decays are single exponentials, with ac ommon value of 0.85 AE 0.1 ( Table 2). In DCM and DMSO the typical features of porphyrin fluorescencea ppear,w hereas in H 2 Oaweaka nd almostf eatureless spectrumi so bserved.…”

“…[11] TPA was studied in DCM containing 1% pyridine to avoid aggregation and in DMSO. [11] TPA was studied in DCM containing 1% pyridine to avoid aggregation and in DMSO.…”

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