Dilatation of the main pancreatic duct of unknown origin: causes and risk factors of pre-malignancy or malignancy

Martin, Antoine; Cros, Jérôme; Vullierme, Marie‐Pierre; Dokmak, Safi; Sauvanet, Alain; Lévy, Philippe; Rebours, Vinciane; Maire, Frédérique

doi:10.1007/s00464-022-09854-y

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…MPD dilatation and growth during surveillance are predictive factors of PC. [5,18,21–23] In a previous study on asymptomatic individuals at high risk for developing PC, approximately 20% showed mild MPD dilatation, which was significantly associated with neoplastic progression. [24] Hence, accurate evaluation and follow-up of MPD dilatation during surveillance are important for detecting an increased risk of PC.…”

Section: Discussionmentioning

confidence: 99%

Correlation between main pancreatic duct diameter measurements: Special pancreatic ultrasonography versus magnetic resonance cholangiopancreatography

Ikezawa,

Fukuda,

Nakao

et al. 2024

Medicine

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Main pancreatic duct (MPD) dilatation is reported to be a risk factor for pancreatic cancer (PC). Although magnetic resonance cholangiopancreatography (MRCP) and ultrasonographic modalities are valuable for monitoring the pancreas, there is limited information on the efficacy of different imaging modalities in measuring MPD diameter. To improve pancreatic imaging, we developed a specialized ultrasound approach focusing on the pancreas (special pancreatic US). We aimed to examine the correlation between MPD diameter measurements using special pancreatic US versus MRCP. We retrospectively reviewed the clinical data of patients with MPD dilation (≥2.5 mm) via special pancreatic US used for screening at our institution between January 2020 and October 2022 and included patients who underwent magnetic resonance imaging 2 months before and after pancreatic US. The MPD diameter on MRCP was measured at the pancreatic locus, where the maximum MPD diameter was obtained on special pancreatic US. This study included 96 patients, with a median interval of 8.5 days between the date of special pancreatic US and the date of undergoing MRCP. MPD dilatation and/or pancreatic cysts were diagnosed in 86 patients, PC in 5 patients, and other diseases in 5 patients. The median MPD diameter, measured using special pancreatic US, was 3.4 mm (interquartile range: 2.9–4.9 mm), whereas it was 3.5 mm using MRCP (interquartile range: 2.8–4.5 mm). There were strong positive correlations between MPD diameter measured on special pancreatic US and that measured on MRCP (R = 0.925, P < .001). This study revealed strong positive correlations between the MPD diameter measurements using special pancreatic US and MRCP. MPD diameter measurements from each imaging method can be helpful during follow-up in individuals at a high risk of PC.

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Section: Discussionmentioning

confidence: 99%

Correlation between main pancreatic duct diameter measurements: Special pancreatic ultrasonography versus magnetic resonance cholangiopancreatography

Ikezawa,

Fukuda,

Nakao

et al. 2024

Medicine

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“…Dilatation of the main pancreatic duct (MPD ) is not a specific symptom and can be a result of a congenital anomaly of the ductal system or the result of various diseases: intraductal papillary mucinous tumor (IPMN), chronic pancreatitis, pancreatic neuroendocrine tumors (NETs), pancreatic adenocarcinoma [ 1–3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The average value of MPD dilatation in various pathologies is 7 mm within the range of 4–35 mm [ 1 ]. Cases with MPD dilatation of more than 50 mm are rare [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Giant dilatation of pancreatic duct associated with congenital anomaly of the pancreatic ductal system and small neuroendocrine tumor

Markov,

Karmazanovsky,

Lysenko

et al. 2024

Journal of Surgical Case Reports

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Dilatation of the main pancreatic duct (MPD) ˃50 mm is a rare phenomenon. We present the case of successful surgical treatment a 63-year-old female patient who presented epigastric pain and weight loss of 10 kg in 6 months. Based on preoperative examination, the dilatation of MPD was 75 mm. The preliminary diagnosis was main duct intraductal papillary mucinous neoplasm. Extended pylorus-preserving pancreatoduodenectomy with resection of the body of the pancreas was performed. According to the results of pathological and immunohistochemical studies, performed by independent experts, the final diagnosis of congenital anomaly of the ductal system and neuroendocrine tumor of the accessory pancreatic duct was made.

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Incidentally detected pancreatic duct dilatation on ultrasound and role of MRI

Bezuidenhout,

Lee,

Mashar

et al. 2024

Abdom Radiol

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Dilatation of the main pancreatic duct of unknown origin: causes and risk factors of pre-malignancy or malignancy

Cited by 5 publications

References 16 publications

Correlation between main pancreatic duct diameter measurements: Special pancreatic ultrasonography versus magnetic resonance cholangiopancreatography

Correlation between main pancreatic duct diameter measurements: Special pancreatic ultrasonography versus magnetic resonance cholangiopancreatography

Giant dilatation of pancreatic duct associated with congenital anomaly of the pancreatic ductal system and small neuroendocrine tumor

Incidentally detected pancreatic duct dilatation on ultrasound and role of MRI

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