Dilated Cardiomyopathy in Children and Adults: What is New?

Elkilany, Galal; Al-Qbandi, Mustafa; Sayed, Khaled; Kabbash, Ibrahim Ali

doi:10.1100/tsw.2008.105

Cited by 7 publications

(5 citation statements)

References 26 publications

(14 reference statements)

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“…found majority of cases of IDCM in younger children in Oman. [1415] Other presenting features were also comparable with the study of AL Jarallah et al . [13] These differences may be attributable to racial basis.…”

Section: Discussionsupporting

confidence: 87%

Pediatric idiopathic dilated cardiomyopathy: A single center experience

Azhar

2013

J Nat Sc Biol Med

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Context:Idiopathic dilated cardiomyopathy (IDCM) is a severe illness with high mortality in the pediatric population. AIMS: To highlight our experience about clinical course and outcome of IDCM.Settings and Design:Patients’ files were reviewed retrospectively for diagnosed cases of IDCM in the pediatric cardiology unit of King Abdul Aziz University Hospital, Jeddah, Saudi Arabia, from Jan 2003 to Jun 2011.Materials and Methods:Data about full history, clinical examination and investigations were recorded and grouped according to outcome as alive and well (group 1), alive and symptomatic (group 2) and worsened or dead (group 3).Statistical Analysis:Data was subjected to descriptive analysis. Chi-square and Student's paired t-test techniques were used where appropriate. Spearman rank correlation and survival analysis was done.Results:Eighty three patients were included with presenting age median (range), i.e.,14 (2 months–12 years) with females predominance 53 (63.9%). On presentation; cardiomegaly was noted in 72 (86.7%) with increased lung vascularity in 45 (54%). Sixty-one (74%) patients had ST segment and T-wave changes on electrocardiogram, while the same number had left ventricular hypertrophy, and 15 (18%) had arrhythmias. Echocardiography records on presentation and at last follow-up showed significant difference in several areas. Group 1 had 40 (48.2%), Group 2 had 23 (27.7%) while 20 (24.1%) were in Group 3 including nine cases who died. Survival rate over three years was 78%. Older the age, worse was the outcome (Spearman's rho = 0.3, P = 0.04).Conclusion:Majority of subjects were presented during first year of life; the three year survival rate was 78%. Favorable outcome was correlated with younger age at presentation.

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Section: Discussionsupporting

confidence: 87%

Pediatric idiopathic dilated cardiomyopathy: A single center experience

Azhar

2013

J Nat Sc Biol Med

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“…Considering the prevalence of non ischemic heart failure (DCM) is 17% [29] , and the worst accepted improvement in E/A ratio is 30% after intervention, the confidence level is 95%, the sample size will be 32. Adding 25% for defaulters, the sample size will be 40.…”

Section: Statistical Analysesmentioning

confidence: 99%

Correlation between changes in diastolic dysfunction and health-related quality of life after cardiac rehabilitation program in dilated cardiomyopathy

Mehani

2013

Journal of Advanced Research

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Chronic heart failure (CHF) is a complex syndrome characterized by progressive decline in left ventricular function, low exercise tolerance and raised mortality and morbidity. Left ventricular diastolic dysfunction plays a major role in CHF and progression of most cardiac diseases. The current recommended goals can theoretically be accomplished via exercise and pharmacological therapy so the aim of the present study was to evaluate the impact of cardiac rehabilitation program on diastolic dysfunction and health related quality of life and to determine the correlation between changes in left ventricular diastolic dysfunction and domains of health-related quality of life (HRQoL). Forty patients with chronic heart failure were diagnosed as having dilated cardiomyopathy (DCM) with systolic and diastolic dysfunction. The patients were equally and randomly divided into training and control groups. Only 30 of them completed the study duration. The training group participated in rehabilitation program in the form of circuit-interval aerobic training adjusted according to 55–80% of heart rate reserve for a period of 7 months. Circuit training improved both diastolic and systolic dysfunction in the training group. On the other hand, only a significant correlation was found between improvement in diastolic dysfunction and health related quality of life measured by Kansas City Cardiomyopathy Questionnaire. It was concluded that improvement in diastolic dysfunction as a result of rehabilitation program is one of the important underlying mechanisms responsible for improvement in health-related quality of life in DCM patients.

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“…One study conducted in New England and the Central Southwest reported an annual incidence of 1.13 per 100,000 infants and children [12]. Another study conducted in Egypt and Kuwait reported an overall rate of dilated cardiomyopathy in childhood of 0.07 cases/100,000/year [15].…”

Section: Incidencementioning

confidence: 99%

Non-Cardiac Cause of Death in Selected Group Children with Cardiac Pathology: A Retrospective Single Institute Study

et al. 2022

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Background: Pediatricians and pediatric surgeons often face children with cardiomegaly and dilatative or hypertrophic cardiomyopathies presenting with or without symptoms. Some of these patients have already been diagnosed and received medication, and some present with completely unrelated pathologies. Methods: We performed a 4-year retrospective study on the causes and mechanisms of death of children with cardiac pathology who died outside the cardiology clinic of our hospital by studying the hospital charts and necropsy reports. All children who were in this situation in our hospital were included. Results: Most children in our study group were infants (81.82%), most were boys (81.82%), and in most cases, the cause or mechanism of death was unrelated to their heart condition, whether it had already been diagnosed or not (one case probably died as a result of a malignant ventricular arrhythmia). Additionally, 27.27% of children died as a consequence of bronchopneumonia, the same percentage died as a consequence of an acquired non-pulmonary disease or after surgery, and 18.18% died as a consequence of congenital malformations. Conclusions: Cardiac disease needs to be thoroughly investigated using multiple tools for all children presenting with heart failure symptoms, those with heart murmurs, and children scheduled for surgery of any type. The intensive care specialist and surgeon need to be aware of any heart pathology before non-cardiac surgical interventions.

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Dilated Cardiomyopathy in Children and Adults: What is New?

Cited by 7 publications

References 26 publications

Pediatric idiopathic dilated cardiomyopathy: A single center experience

Pediatric idiopathic dilated cardiomyopathy: A single center experience

Correlation between changes in diastolic dysfunction and health-related quality of life after cardiac rehabilitation program in dilated cardiomyopathy

Non-Cardiac Cause of Death in Selected Group Children with Cardiac Pathology: A Retrospective Single Institute Study

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