Dilated retinal large vessels and capillaries associated with diabetic macular edema and photoreceptor loss respectively

Lei, Jianqin; Xu, Xiayu; Chen, Li; Fan, Xiaojuan; Abdelfattah, Nizar Saleh

doi:10.1007/s00417-020-05039-2

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…The presence of EZ disruption was approximately two times more frequent according to ELM disruption in our subjects. In a recent study, Lei et al reported that EZ disruptions were found in 40% of diabetic eyes [24]. Our sectoral results were comparable, but their subjects had 57% DME, while all of eyes in our study group had DME.…”

Section: Discussionsupporting

confidence: 65%

“…The SCP includes larger vessels (arterioles and venules) beside the capillaries. Additionally, it was found that the diameter of large vessels steadily increased from diabetes without retinopathy to more severe stages of diabetic retinopathy in SCP [24]. Vessel length and vessel caliber affect vessel density [25].…”

Section: Discussionmentioning

confidence: 97%

“…They used SD-OCT; however, we used SS-OCT, which was con rmed to have better deep resolution. Some researchers suggested that outer retinal disruptions were correlated with SCP changes, while some reported DCP partially contributed [13,14,24]. DCP provides approximately 15% of the oxygen supply of the photoreceptors, while the outer one-third of the retina is mainly supplied by the choriocapillaris [34].…”

Section: Discussionmentioning

confidence: 99%

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Automated Sectoral Quantitative Analysis of Parafoveal Microvascular Status and Association with Structure in Diabetic Macular Edema

Polat

Yoloğlu

2021

Preprint

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Purpose: To evaluate the integrity of the capillary plexuses, their relationship with each other, and their association with structural changes in a sectoral manner in diabetic macular edema (DME).Methods: The vessel density (VD) was measured in inferior, superior, nasal and temporal (İ, S, N, T) parafovea in the superficial capillary plexus (SCP) and deep capillary plexus (DCP). The integrity of the external limiting membrane (ELM) and ellipsoid zone (EZ) were evaluated in B-scan images.Results: In the SCP, only superior and nasal VD was significantly lower (P: 0.0001 and P: 0.020, respectively) while in the DCP, only temporal VD was significantly lower in the DME eyes (P: 0.034). There was no correlation between the VD of SCP and DCP in the corresponding quadrants (all P > 0.05). The FAZ area was significantly greater (both superficial and deep) in DME eyes than in control eyes (P > 0.05). ELM disruptions were not affected by the corresponding VDs in the SCP (all P> 0.05), but nasal and temporal quadrant ELM disruptions were affected by VDs in the DCP in the corresponding quadrants (P: 0.005 nasal, P: 0.001 temporal). EZ disruptions were not affected by the corresponding VDs in the SCP and DCP (all P> 0.05).Conclusions: The SCP was affected in more quadrants than the DCP and probably independently from each other. There was an association with the ELM and the DCP, especially in nasal and temporal quadrants, but there was not an association between the EZ and SCP or DCP.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Automated Sectoral Quantitative Analysis of Parafoveal Microvascular Status and Association with Structure in Diabetic Macular Edema

Polat

Yoloğlu

2021

Preprint

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Computer-assisted evaluation of retinal vessel tortuosity in children with sickle cell disease without retinopathy

Raffa,

Hervella

et al. 2025

Microvascular Research

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In vivo assessment of associations between photoreceptors structure and macular perfusion in type 1 diabetes

et al. 2022

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PurposeTo explore the potential relationships between macular vascular network and different adaptive optics (AO) metrics in patients with type 1 diabetes mellitus (DM1) with no signs (NoDR) or mild non-proliferative diabetic retinopathy (NPDR).DesignObservational cross-sectional study.MethodsForty eyes of consecutive patients with DM1 (12 NoDR and 28 NPDR) and 10 healthy age-matched control subjects were included. All patients and controls were imaged using AO retinal camera and PLEX Elite 9000 optical coherence tomography (OCT) angiography (OCTA). The AO outcome measures to evaluate the cone photoreceptor mosaic characteristics were as follows: (1) Cone density (CD); (2) Linear Dispersion Index (LDi) and (3) Heterogeneity Packing Index (HPi). The OCTA outcome measures included: (1) superficial capillary plexus (SCP) perfusion density (PD); (2) deep capillary plexus (DCP) PD and (3) the choriocapillaris (CC) flow deficit percentage (FD%).ResultsNPDR group exhibited a close relationship between cone metrics and CC FD. Notably, CC FD% increase along with LDi (p=0.035), while the increasing CC FD% were associated with reducing CD (p=0.042) and the HPi (p=0.017). Furthermore, the OCTA parameters, including PD SCP and DCP, showed a significant negative correlation with CD.ConclusionsOur results demonstrated the relationship between macular perfusion at both retinal and choroidal levels and the cone mosaic in patients with DM1 interpolating swept-source-OCTA and AO metrics. In NPDR eyes, the photoreceptor damage was accompanied by CC insufficiency since the early stages of the disease.

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Dilated retinal large vessels and capillaries associated with diabetic macular edema and photoreceptor loss respectively

Cited by 4 publications

References 23 publications

Automated Sectoral Quantitative Analysis of Parafoveal Microvascular Status and Association with Structure in Diabetic Macular Edema

Automated Sectoral Quantitative Analysis of Parafoveal Microvascular Status and Association with Structure in Diabetic Macular Edema

Computer-assisted evaluation of retinal vessel tortuosity in children with sickle cell disease without retinopathy

In vivo assessment of associations between photoreceptors structure and macular perfusion in type 1 diabetes

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