DIlp7-Producing Neurons Regulate Insulin-Producing Cells in Drosophila

Prince, Elodie; Kretzschmar, Jenny; Trautenberg, Laura Christin; Broschk, Susanne; Brankatschk, Marko

doi:10.3389/fphys.2021.630390

Cited by 6 publications

(5 citation statements)

References 56 publications

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“…Least is known about ILP7 and especially ILP4. Recent work shows that, in addition to ILP8, ILP7 is able to bind Lgr3 ( Meissner et al, 2016 ; Prince et al, 2021 ). ILP7 acts upstream of IPC-derived ILPs to maintain IIS while the availability of dietary amino acids is low.…”

Section: Insulinmentioning

confidence: 99%

Endocrine Regulation of Lifespan in Insect Diapause

Hutfilz

2022

Front. Physiol.

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Diapause is a physiological adaptation to conditions that are unfavorable for growth or reproduction. During diapause, animals become long-lived, stress-resistant, developmentally static, and non-reproductive, in the case of diapausing adults. Diapause has been observed at all developmental stages in both vertebrates and invertebrates. In adults, diapause traits weaken into adaptations such as hibernation, estivation, dormancy, or torpor, which represent evolutionarily diverse versions of the traditional diapause traits. These traits are regulated through modifications of the endocrine program guiding development. In insects, this typically includes changes in molting hormones, as well as metabolic signals that limit growth while skewing the organism’s energetic demands toward conservation. While much work has been done to characterize these modifications, the interactions between hormones and their downstream consequences are incompletely understood. The current state of diapause endocrinology is reviewed here to highlight the relevance of diapause beyond its use as a model to study seasonality and development. Specifically, insect diapause is an emerging model to study mechanisms that determine lifespan. The induction of diapause represents a dramatic change in the normal progression of age. Hormones such as juvenile hormone, 20-hydroxyecdysone, and prothoracicotropic hormone are well-known to modulate this plasticity. The induction of diapause—and by extension, the cessation of normal aging—is coordinated by interactions between these pathways. However, research directly connecting diapause endocrinology to the biology of aging is lacking. This review explores connections between diapause and aging through the perspective of endocrine signaling. The current state of research in both fields suggests appreciable overlap that will greatly contribute to our understanding of diapause and lifespan determination.

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Section: Insulinmentioning

confidence: 99%

Endocrine Regulation of Lifespan in Insect Diapause

Hutfilz

2022

Front. Physiol.

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“…Relaxin subfamily in vertebrates plays diverse roles in tissue homeostasis and remodeling, behavior, and reproduction (Gundlach et al., 2009). Recent reports indicate that ilp7‐Lgr4 signaling works as circuit gates for escape behavior (Prince et al., 2021). The investigation of how glial and non‐CNS tissue expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.…”

Section: Discussionmentioning

confidence: 99%

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Miao,

Wei,

Lee

et al. 2023

J of Neuroscience Research

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Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carries out specific functions. Glial GPCRs play key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. A recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells disrupts Drosophila development, while knocking down other LGR family members in glia has no impact. Adult‐specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.

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“…Relaxin subfamily in vertebrates play diverse roles in tissue homeostasis and remodeling, behaviour and reproduction [21]. Recent reports indicate that ilp7-Lgr4 signaling works as circuit gates for escape behavior [30]. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.…”

Section: Discussionmentioning

confidence: 99%

Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Lee

Kaur

Miao

et al. 2022

Preprint

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Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carry out specific functions. Glial GPCRs plays key roles in crosstalk between neurons and glia. Drosophila Lgr4 (dLgr4) is a human relaxin receptor homolog involved in angiogenesis, cardiovascular regulation, collagen remodeling, and wound healing. Recent study suggests that ilp7 might be the ligand for Lgr4 and regulates escape behavior of Drosophila larvae. Here we demonstrate that Drosophila Lgr4 expression in glial cells, not neurons, is necessary for early development, adult behavior, and lifespan. Reducing the Lgr4 level in glial cells, but not neurons, disrupts Drosophila development, although knocking down other LGR family members in glia has no impact. Adult-specific knockdown of Lgr4 in glia but not neurons reduce locomotion, male reproductive success, and animal longevity. The investigation of how glial expression of Lgr4 contributes to this behavioral alteration will increase our understanding of how insulin signaling via glia selectively modulates neuronal activity and behavior.

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DIlp7-Producing Neurons Regulate Insulin-Producing Cells in Drosophila

Cited by 6 publications

References 56 publications

Endocrine Regulation of Lifespan in Insect Diapause

Endocrine Regulation of Lifespan in Insect Diapause

Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

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