Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Binder, Ellen F.; Cayabyab, Lillibeth; Ritchie, David J.; Birge, Stanley J.

doi:10.1001/archinte.1991.00400020119023

Cited by 23 publications

(2 citation statements)

References 19 publications

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“…Early reports indicate problems when lithium is used in conjunction with calcium channel blockers, perhaps due to a synergistic calcium antagonist effect (Binder et al 1991;Wright & Jarrett 1991). Nonpsychiatric drugs, such as methyldopa, are also occasionally associated with neurotoxicity when given with lithium (Byrd 1975(Byrd ,1977O'Regan 1976;Osanloo & Deglin 1980).…”

Section: Neurotoxic Combinationsmentioning

confidence: 99%

Review of Clinically Important Drug Interactions with Lithium

Harvey

Merriman

1994

Drug Safety

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The therapeutic dosage of lithium is close to the toxic level, and drugs reducing the renal clearance of lithium can produce the most serious adverse effects. When used in combination with psychiatric drugs affecting mood, the therapeutic potential of lithium may be enhanced, and earlier concern regarding possible neurotoxic interactions with neuroleptics appear poorly substantiated. A number of specific interactions of low incidence have also been reported which should be borne in mind when new medications are introduced. The ready availability of lithium concentration monitoring in body fluids makes it possible to alter the effects of some potentially interactive drugs that may still need to be given in combination with lithium.

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Section: Neurotoxic Combinationsmentioning

confidence: 99%

Review of Clinically Important Drug Interactions with Lithium

Harvey

Merriman

1994

Drug Safety

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“…1,2 These combinations sometimes may lead to different adverse effects. [3][4][5][6][7] A combination of lithium and conventional antipsychotic agents is usually well tolerated. However, various forms of toxicity have been described when lithium and different psychotropic medications are used in combination.…”

mentioning

confidence: 99%

Lithium Intoxication Associated With Intramuscular Ziprasidone in Schizoaffective Patients

Miodownik

Hausmann²,

Frolova³

et al. 2005

Clinical Neuropharmacology

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Antipsychotic agents have been used for the treatment of mood disorders in schizophrenic and schizoaffective patients. It has also been suggested that combinations of lithium and antipsychotics may be more effective than either class alone in treatment of schizoaffective patients. Lithium is known to interact with a variety of medications, including conventional and atypical antipsychotics. Although these combinations are generally well tolerated, they may sometimes lead to various adverse side effects. The authors report two schizoaffective patients with manic psychotic state and psychomotor agitation treated with lithium. Both patients developed symptoms of lithium intoxication after intramuscular ziprasidone treatment. To the best of their knowledge, this is the first description of such an adverse effect of this new atypical neuroleptic drug. They assume that lithium intoxication in the two presented cases was associated with the fast increase of ziprasidone serum level after its parenteral application, possibly affecting lithium excretion and thereby leading to lithium intoxication.

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The Myoneural Effects of Lithium Chloride on the Nerve–muscle Preparations of Rats. Role of Adenosine Triphosphate-Sensitive Potassium Channels

Abdel-Zaher

2000

Pharmacological Research

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Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Cited by 23 publications

References 19 publications

Review of Clinically Important Drug Interactions with Lithium

Review of Clinically Important Drug Interactions with Lithium

Lithium Intoxication Associated With Intramuscular Ziprasidone in Schizoaffective Patients

The Myoneural Effects of Lithium Chloride on the Nerve–muscle Preparations of Rats. Role of Adenosine Triphosphate-Sensitive Potassium Channels

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