Diltiazem Inhibits the Spontaneous Platelet Aggregation in Essential Hypertension

Pechán, J; Okrucká, A

doi:10.1159/000174868

Cited by 14 publications

(1 citation statement)

References 12 publications

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“…Moreover, it has been shown that Ang II increases [Ca 2+ ] i and pH in platelets from hypertensive patients, which may be associated with enhanced platelet aggregation [54]. In hypertension, platelets showed spontaneous aggregation and increased sensitivity to agonists [55, 56]. Furthermore, platelets release more β-thromboglobulin and P-selectin and have higher intracellular Ca 2+ levels [57, 58].…”

Section: Role Of Platelet Hyperactivity In the Development Of Cvdmentioning

confidence: 99%

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

O’Kennedy

Raederstorff²,

Duttaroy

2016

Eur J Nutr

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Hyperactive platelets, in addition to their roles in thrombosis, are also important mediators of atherogenesis. Antiplatelet drugs are not suitable for use where risk of a cardiovascular event is relatively low. It is therefore important to find alternative safe antiplatelet inhibitors for the vulnerable population who has hyperactive platelets in order to reduce the risk of cardiovascular disease. Potent antiplatelet factors were identified in water-soluble tomato extract (Fruitflow®), which significantly inhibited platelet aggregation. Human volunteer studies demonstrated the potency and bioavailability of active compounds in Fruitflow®. Fruitflow® became the first product in Europe to obtain an approved, proprietary health claim under Article 13(5) of the European Health Claims Regulation 1924/2006 on nutrition and health claims made on foods. Fruitflow® is now commercially available in different countries worldwide. In addition to its reduction in platelet reactivity, Fruitflow® contains anti-angiotensin-converting enzyme and anti-inflammatory factors, making it an effective and natural cardio-protective functional food.

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Section: Role Of Platelet Hyperactivity In the Development Of Cvdmentioning

confidence: 99%

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

O’Kennedy

Raederstorff²,

Duttaroy

2016

Eur J Nutr

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Human Blood Platelets and Their Role in the Development of Cardiovascular Disease

2018

Nutraceuticals and Human Blood Platelet Function

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Diltiazem: Ten Years of Clinical Experience in the Treatment of Hypertension

Weir

1995

The Journal of Clinical Pharma

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Diltiazem hydrochloride is a benzothiazepine derivative calcium-channel blocker with proven antianginal and antihypertensive capabilities. Its primary mechanism of action is vasodilatation, which results in diminished vascular resistance and improved perfusion to various vascular beds and target organs. The antihypertensive efficacy of diltiazem in various demographic groups has been studied and compared with diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, and other calcium-channel blockers. These studies have shown that the antihypertensive effect of diltiazem is similar to that of the other therapies. Diltiazem does not adversely affect electrolytes or carbohydrate or lipid metabolism, and it may have beneficial effects on the heart and kidneys. Diltiazem reduces myocardial hypertrophy and exerts antianginal effects on the heart through coronary vasodilation and reduction in the blood pressure double product. Diltiazem improves renal perfusion and attenuates proteinuria. These effects may be helpful in limiting the progression of renal injury. Overall, the efficacy and tolerability of diltiazem, as well as its salutary effects on the heart and kidneys, make it an important therapeutic consideration for patients with hypertensive disease.

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Diltiazem Inhibits the Spontaneous Platelet Aggregation in Essential Hypertension

Cited by 14 publications

References 12 publications

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

Fruitflow®: the first European Food Safety Authority-approved natural cardio-protective functional ingredient

Human Blood Platelets and Their Role in the Development of Cardiovascular Disease

Diltiazem: Ten Years of Clinical Experience in the Treatment of Hypertension

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