Dilute-and-shoot-based direct nano-electrospray ionization tandem mass spectrometry as screening methodology for multivitamins in dietary supplement and human urine

Amer, Sara; Zarad, Walaa; El-Gendy, Heba; Salam, Randa A. Abdel; Hadad, Ghada M.; Emara, Samy; Masujima, Tsutomu

doi:10.1016/j.jare.2020.06.009

Cited by 3 publications

(1 citation statement)

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“…Matrix effect is the most intractable issue in ionization for liquid chromatography‐MS (LC‐MS), particularly for biomolecular measurements. Therefore, how to efficiently reduce the matrix effect and promote ionization is an attractive direction, and the vast majority of new technologies have been developed, including nano‐ESIMS (Amer et al, 2020; McMahon et al, 2016), probe‐ESIMS (Yamashiro & Watanabe, 2017; Zheng et al, 2020), desorption‐ESIMS (Honarvar & Venter, 2018; Parrot et al, 2018), laser ablation ESIMS (Pereira et al, 2019; van Geenen et al, 2020) and capillary ESIMS (Konášová et al, 2021; Szigeti & Guttman, 2019).…”

Section: Revolutionary Single‐cell Ms Analysismentioning

confidence: 99%

Proteomics mining of cancer hallmarks on a single‐cell resolution

Zuo

Yang

et al. 2023

Mass Spectrometry Reviews

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Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and numerous cell subtypes have been characterized that greatly influence cancer progression. Population‐averaged research may not fully reveal the heterogeneity, leading to inaccurate conclusions. Thus, deep mining of the multiplex proteome at the single‐cell resolution will provide new insights into cancer biology, to develop prognostic biomarkers and treatments. Considering the recent advances in single‐cell proteomics, herein we review several novel technologies with particular focus on single‐cell mass spectrometry analysis, and summarize their advantages and practical applications in the diagnosis and treatment for cancer. Technological development in single‐cell proteomics will bring a paradigm shift in cancer detection, intervention, and therapy.

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