Diluted Fecal Community Transplant Restores Clostridioides difficile Colonization Resistance to Antibiotic-Perturbed Murine Communities

Abstract

Antibiotic use, ubiquitous with the health care environment, is a major risk factor for Clostridioides difficile infection (CDI), the most common nosocomial infection. When C. difficile becomes resistant to antibiotics, a fecal microbiota transplant from a healthy individual can effectively restore the gut bacterial community and eliminate the infection.

Antibiotic Conditioning Shapes Pseudosterile Mouse Models by Deleting Colonic Microbes Rather than Small Intestinal Microbes

“…Clindamycin hydrochloride, the antibiotic selected in this study, primarily targets strict anaerobic species ( 35 ). In addition, ampicillin and cefoperazone sodium salt are generally active against Gram-negative and Gram-positive bacteria in the intestinal tract, such as Enterobacteriaceae ( 36 , 37 ).…”