This paper proposes a fused lasso model to identify significant features in the spectroscopic signals obtained from a semiconductor manufacturing process, and to construct a reliable virtual metrology (VM) model. Analysis of spectroscopic signals involves combinations of multiple samples collected over time, each with a vast number of highly correlated features. This leads to enormous amounts of data, which is a challenge even for modern-day computers to handle. To simplify such complex spectroscopic signals, dimension reduction is critical. The fused lasso is a regularized regression method that performs automatic variable selection for the predictive modeling of highly correlated datasets such as those of spectroscopic signals. Furthermore, the fused lasso is especially useful for analyzing highdimensional data in which the features exhibit a natural order, as is the case in spectroscopic signals. In this paper, we conducted an experimental study to demonstrate the usefulness of a fused lasso-based VM model and compared it with other VM models based on the lasso and