The modern practice of forensic anthropology is focused on the quantification of skeletal variation based upon a qualitative prowess developed according to theory and method in the parent discipline of biological anthropology. Such morphological variances allow estimates of biological attributes, for example, age, sex, population affinity, stature, pathology of disease processes-among others, that collectively may resolve the identification of unknown forensic human remains.The latter is a basic human right under International Humanitarian Law (IHL), and International Human Rights Law (IHRL) afforded to descendants who go missing in armed conflicts and other violence-base situations. The specific traditional methods applied by the forensic anthropologist are well established in the published literature and routinely supported by global research that guides graduate programs designed to train the next generation of practitioners. Important in that cornerstone literature and graduate training regimen are aspects of our practice that are increasingly cross-disciplinary, especially those grounded in the molecular, chemical, and histological sciences. These upper-tier endeavors supplement and many times, validate, the traditional approaches as dictated by case context. This review focuses on evolving cross-disciplinary developments and novel research trends in the analysis of human remains that involve the specific expertise of the forensic anthropologist.