2019
DOI: 10.1192/bjo.2019.68
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Dimensional anhedonia and the adolescent brain: reward and aversion anticipation, effort and consummation

Abstract: Background Given the heterogeneity of depression the Research Domain Criteria Framework suggests a dimensional approach to understanding the nature of mental illness. Neural reward function has been suggested as underpinning the symptom of anhedonia in depression but how anhedonia is related to aversion processing is unclear. Aims To assess how the dimensional experience of anhedonia and depression severity relate to reward and aversion processing in the human brain. Method … Show more

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Cited by 20 publications
(23 citation statements)
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“…The sucrose preference test is an indicator of anhedonia-like behavioral change. Anhedonia a core symptom of major depression among humans is modeled by inducing a decrease in responsiveness to rewards, as reflected by the reduced consumption of and/or preference for sweetened solutions (Rzepa and McCabe, 2019). In the present study, the data are in line with previous findings showing that a significant decrease in the percentage of sucrose consumption of mice (Cerniauskas et al, 2019).…”
Section: Sucrose Consumptionsupporting
confidence: 91%
“…The sucrose preference test is an indicator of anhedonia-like behavioral change. Anhedonia a core symptom of major depression among humans is modeled by inducing a decrease in responsiveness to rewards, as reflected by the reduced consumption of and/or preference for sweetened solutions (Rzepa and McCabe, 2019). In the present study, the data are in line with previous findings showing that a significant decrease in the percentage of sucrose consumption of mice (Cerniauskas et al, 2019).…”
Section: Sucrose Consumptionsupporting
confidence: 91%
“…In our follow-up, much larger study currently under review, we found participants with depression symptoms invested less physical effort to gain the positive rewarding stimulus than controls and had blunted neural anticipation of positive and negative stimuli in the precuneus, insula, and PFC (left dlPFC and lOFC) and blunted neural effort for positive in the putamen [75]. As the dlPFC is involved in cognitive control and in executive functions [47], we suggest dysfunction in this region might indicate a mechanism by which reduced planning to gain positive and avoid negative stimuli might arise in those with depression symptoms.…”
Section: The Role Of the Pfc In Depression And The Processing Of Pmentioning
confidence: 99%
“…There is also a reward learning step whereby predictions can be made about positive outcomes (Treadway & Zald, 2011). Further, a recent study found that in adolescents with depression symptoms anhedonia correlated with decreased physical motivation (effort) to gain reward (Rzepa & McCabe, 2019). However, it is less clear which aspects of the reward process are the most impaired or problematic in adolescents with depression (McCabe, 2018).…”
mentioning
confidence: 99%