The Cantareira Water Production System (CWPS), which supplies water to the most populous region in Brazil, is facing significant challenges due to hydroclimate change, thus threatening its water security. This research integrates data from climate models and field observations with hydrological modeling, aimed at quantifying trends in key variables of the hydrological cycle. The GFDL-CM4 climate model, the most suitable for the study area, was employed to generate runoff data under both current conditions and future scenarios (SSP2-4.5 and SSP5-8.5). Our analysis reveals an increasing trend in the frequency of dry hydrological years. The Standard Precipitation Index (SPI) and Drought Magnitude (DM) confirm an increase in both the occurrence and duration of droughts in future scenarios. The runoff in all basins was reduced, causing a substantial decrease in minimum flows of 16.9%, medium flows of 11.8%, and high flows of 9.2% for the SSP5-8.5 scenario. This research introduces an approach to hydroclimate impact assessment, combining rigorous data analysis with advanced modeling techniques. Our findings not only provide a comprehensive understanding of the challenges faced by the CWPS, but also offer critical quantitative insights essential for developing effective public policies and adaptive strategies for sustainable water resource management.