Dimensional effect of graphene nanostructures on cytoskeleton‐coupled anti‐tumor metastasis

Abstract

Interactions between inorganic materials and living systems can be strongly influenced by the dimensional property of the materials, which can in turn impact biological activities. Although the role of biomaterials at the molecular and cellular scales has been studied, research investigating the effects of biomaterials across multiple dimensional scales is relatively scarce. Herein, comparing the effectiveness of two‐dimensional graphene oxide nanosheets (GOs) and three‐dimensional graphene oxide quantum dots (GOQDs) (though not zero‐dimensional because of their significant surface area) in cancer therapies, we have discovered that GOs, with the same mass concentration, exhibit stronger anti‐cancer and anti‐tumor metastasis properties than GOQDs. Our research, which employed liquid‐phase atomic force microscopy, revealed that lower‐dimensional GOs create a more extensive nano‐bio interface that impedes actin protein polymerization into the cytoskeleton, leading to the prevention of tumor metastasis. These results help to better understand the underlying mechanisms and offer a dimensional perspective on the potential of optimizing the properties of graphene‐based materials for clinical applications, e.g., cancer therapy.

0D Amplification Strategies Reshape Bone Interface Niches via Biointernalization Effects

“…[ 9 ] Additionally, 0DBMs can function as carriers of biological cues while also inducing cellular behaviors, thereby intensifying and extending the regulation of cell fate by biological cues. [ 10 ] For instance, Paul et al discovered that gold nanoparticles alone can influence the expression of pluripotency marker genes in hESCs to some degree, and when combined with FGF‐2, they can enhance the pluripotency of ESCs. [ 11 ] However, the inherent toxicity and metabolic concerns associated with metallic 0D biomaterials restrict their applicability for tissue regeneration.…”