2003
DOI: 10.2460/ajvr.2003.64.618
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Dimensions and histologic characteristics of the small intestine of dogs during postnatal development

Abstract: Increases in intestinal dimensions provide growing dogs with a greater capacity for digestion and absorption. Changes in mucosal architecture and cell populations coincided with shifts in dietary inputs. These findings may assist in the diagnosis of small intestinal diseases and nutritional responses during growth and development of dogs.

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Cited by 41 publications
(43 citation statements)
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“…Several examples of Class II and III evidence‐based data were found in the Group's review of the scientific literature. Most of the studies employed microscopic evaluation of hematoxylin and eosin (HE) stained tissues, 21–23,35–39 whereas others used IHC to label and count leukocyte populations 11–13,40–48 . Representative examples from the GI Standardization Group's archives have been published already, 3 but summaries of studies in each anatomic area follow.…”
Section: Normal Histology Of the Gastrointestinal Tractmentioning
confidence: 99%
See 1 more Smart Citation
“…Several examples of Class II and III evidence‐based data were found in the Group's review of the scientific literature. Most of the studies employed microscopic evaluation of hematoxylin and eosin (HE) stained tissues, 21–23,35–39 whereas others used IHC to label and count leukocyte populations 11–13,40–48 . Representative examples from the GI Standardization Group's archives have been published already, 3 but summaries of studies in each anatomic area follow.…”
Section: Normal Histology Of the Gastrointestinal Tractmentioning
confidence: 99%
“…Several studies have evaluated the normal canine and feline duodenal mucosa with HE and immunohistochemical staining 43,47,49,50 . The normal villus length for an adult dog is 722 ± 170 μm, the normal crypt depth is 1,279 ± 203 μm, and the normal villus to crypt ratio is 0.7 ± 0.3 39,49,50 . Normal dogs have a mean number of 3.6 ± 3.6 goblet cells per stretch of 100 villous enterocytes, and 9.3 ± 3.1 goblet cells per stretch of 100 cryptal enterocytes 43 .…”
Section: Normal Histology Of the Gastrointestinal Tractmentioning
confidence: 99%
“…Furthermore, to fuel ontogenetic growth and provide the developing body with the tissue necessary for digestion and absorption of high dietary loads, the small intestine is relatively larger in juveniles. For example, Beagle puppies at PW9 have, relative to body mass, a small intestine that is 33% longer, weighs 45% more, has 40% more mucosa and 35% more surface area than adults (Paulsen et al, ). Taken together, the growth patterns of the inner organs and particularly of the small intestine are in accordance with a cranial shift of the limbs' support roles.…”
Section: Discussionmentioning
confidence: 99%
“…Data on the histological changes in the intestinal morphology in dependence on physiological processes, however, are very sparse. Suckling puppies exhibit rapid changes in the mucosal morphology that reach a comparatively stable state by the 42 nd d of life [1] . In old dogs, Lafora body-like polyglucosan bodies have been described in the smooth musculature [2] and amyloid in the vessel walls of the large and small intestine without functional or neurological abnormalities [3] .…”
Section: Introductionmentioning
confidence: 99%