Dimensions and Outcome of Synovial Sarcoma of the Head and Neck: Case Presentation and Review of the Literature

Šimunjak, Boris; Petric, Vlado; Bedekovic, Vlado; Čupić, Hrvoje; Hat, Josip

doi:10.2310/7070.2005.34611

Cited by 8 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, our knowledge of the behavior of these tumors is based on case reports and single-institution studies as well as treatment of these tumors in the extremities where they more commonly present. 11,16,19,21,23,25 Use of the SEER database allows for the analysis of treatment and outcomes of rare malignancies such as SCSHN with a greater statistical power than would be achievable through conventional chart review. The SEER database has been used to find determinants of survival in many types of head and neck cancer and has been validated in previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Despite limited primary evidence in the literature with such a rare and poorly studied disease, there is near unanimous support for treatment with wide surgical resection and postoperative adjuvant therapy for locoregional control of SCSHN, with the benefit of chemotherapy remaining controversial. 5,11–15,17,19,23–28 …”

Section: Discussionmentioning

confidence: 99%

“…At present, the mainstay of treatment includes complete resection with wide margins to limit local recurrence. 5,11–15,17,19,23–28 The extent of the resection must factor in the propensity of these tumors to spread beyond the visible or palpable limits of tumor. Radiotherapy is typically employed to improve local control if resection is inadequate.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck

Clair

Arshi

Abemayor

et al. 2016

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Importance: Synovial cell sarcoma of the head and neck (SCSHN) is a rare tumor associated with significant morbidity and mortality. The literature regarding these tumors is limited to case series and case reports. We utilized data from the population-based United States SEER cancer registry to determine factors affecting both overall survival and disease specific survival of patients with SCSHN. Objective: To determine the clinicopathologic and therapeutic factors determining survival in patients with SCSHN. Design, Setting, and Participants: The Surveillance, Epidemiology, and End Results registry was reviewed for patients with primary SCSHN from 1973–2011. Interventions: None Main Outcomes and Measures: Overall survival (OS) and disease-specific survival (DSS). Results: A total of 167 cases of SCSHN were identified. The median age at diagnosis was 37 and 59.9% of patients were males. The mono-phasic spindle cell and biphasic variants were the most common histological subtypes. Surgical resection and radiation therapy were performed in 89.8% and 64.7% of cases, respectively. The median overall survival (OS) at 2, 5, and 10 years was 77%, 66%, and 53%, respectively. Univariate Kaplan-Meier survival analysis revealed that age, race, stage, and size were associated with improved survival. Histological subtype was not associated with significant differences in survival. Radiotherapy was associated with improved disease-specific survival (p=0.003), while surgical management was not associated with improved survival. Multivariate Cox regression analysis revealed that size >5 cm (p=0.007) and stage at presentation (p=0.003) were independent determinants of OS. When separately analyzing cohorts with tumors ≤5 cm and >5 cm, stage at presentation was found to be a significant predictor of survival in both (p=0.003, p=0.010); surgical resection and radiotherapy were not associated with differential survival outcomes using this model. Conclusion and Relevance: SCSHN is an extremely rare malignancy. Independent significant determinants of survival include size >5 cm and stage at presentation. Histological subtype of the tumor is not a significant predictor of survival. Surgical resection and radiation therapy were not found to be independent determinants of survival.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck

Clair

Arshi

Abemayor

et al. 2016

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Head and neck synovial cell sarcoma has a greater metastatic risk than in synovial cell sarcoma found in extremities . Regional metastases occur in 12.5% of patients with head and neck synovial cell sarcoma, and up to 25% of patients present with distant metastases . The primary mode of spread is thought to be hematogenous, but up to 20% of documented metastases show spread to adjacent lymph nodes …”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Less than 5 per cent occur in the parapharyngeal spaces; some 150 patients have been described 4 . In this location it usually presents as a subacute cervical enlargement that cannot be distinguished clinically from a RGTM.…”

mentioning

confidence: 99%

The rapidly growing thyroid mass

Sitges‐Serra

2006

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Dimensions and Outcome of Synovial Sarcoma of the Head and Neck: Case Presentation and Review of the Literature

Cited by 8 publications

References 0 publications

Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck

Factors Associated With Survival in Patients With Synovial Cell Sarcoma of the Head and Neck

Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma

The rapidly growing thyroid mass

Contact Info

Product

Resources

About