The present study examined the relationship between self-compassion (SC) and emotional well-being in college students during the COVID-19 pandemic. The theoretical framework for the study was that SC, defined as an understanding and caring response to one’s suffering and limitations, may serve as a protective factor against negative mental health outcomes. A sample of college students (N = 101) completed self-report measures of SC, depression, anxiety, stress, life satisfaction and subjective happiness. Data were analysed using regression analysis to examine the prediction of emotional well-being variables by SC and moderation analysis to examine the moderating effect of SC on the relationships between emotional well-being variables. The study’s results confirmed the hypothesis that SC would predict emotional well-being. SC significantly predicted all variables examined, including depression, anxiety, stress, life satisfaction (LS) and subjective happiness (SH). However, SC did not moderate the relationships between these variables. Isolation significantly moderated the relationship between SH and depression among college students. These findings support the idea that SC may serve as a protective factor against negative mental health outcomes and suggest that interventions aimed at increasing SC may improve mental health and overall well-being in college students during the COVID-19 pandemic. Further research is needed to understand these relationships’ mechanisms and the factors that may influence them.