Dimercaptosuccinic acid (DMSA) renal scan in the evaluation of hypertension in children

Ahmed, Maheen; Eggleston, Daniel E.; Kapur, Gaurav; Jain, Amrish; Valentini, Rudolph P.; Mattoo, Tej K.

doi:10.1007/s00467-007-0656-2

Cited by 37 publications

(20 citation statements)

References 20 publications

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“…Indeed, some clinical characteristics might help in diagnosing the etiology of hypertension, but they were not fully conclusive. On the other hand, it is very important to distinguish primary and secondary hypertension for avoiding extensive investigation of the etiology of hypertension in children with primary hypertension, but without missing the detection of secondary hypertension [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Primary versus secondary hypertension in children followed up at an outpatient tertiary unit

et al. 2010

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Childhood hypertension has classically been recognized as a secondary disease. However, primary hypertension also occurs in children. The aim of this study was to compare clinical features of pediatric patients with elevated blood pressure, which were referred to an outpatient tertiary unit, and to detect variables associated with the identification of primary hypertension. The records of 220 patients with hypertension followed between 1996 and 2006 were analyzed. The variable of interest was primary hypertension. Logistic regression analysis was applied to identify clinical variables that were independently associated with primary hypertension. Of 220 patients, 33 (15%) had primary hypertension, and 187 (85%) exhibited secondary hypertension. No statistically significant differences were detected in gender, race, age at diagnosis, and systolic/diastolic blood pressure levels between both groups. After adjustment, four variables at baseline remained independently associated with primary hypertension: absence of signs/symptoms (OR 18.87, 95% CI 6.32-56.29), normal serum creatinine (OR 0.02, 95% CI 0.00-0.27), family history of hypertension (OR 3.03, 95% CI 1.04-8.79), and elevated body weight (OR 1.06, 95% CI 1.02-1.10). The absence of signs/symptoms, normal serum creatinine, family history of hypertension, and overweight/obesity at admission are clues to diagnose primary hypertension in childhood.

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Section: Introductionmentioning

confidence: 99%

Primary versus secondary hypertension in children followed up at an outpatient tertiary unit

et al. 2010

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“…In one study, 21% of the children with newly diagnosed hypertension had hypertension etiology showing renal scarring (12) . During 27 years of follow-up, Jacobson concluded that the incidence of HT was 23% in cases with pyelonephritic scars secondary to reflux nephropathy (13) .…”

Section: Discussionmentioning

confidence: 98%

Frequency of Hypertension with Ambulatory Blood Pressure Monitoring in Children with Renal Damage

Çonkar¹

2017

BUCH

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Objective: To determine the frequency of hypertension in children with renal scarring. Methods: The present study was conducted between February 2013 and April 2015 in the Department of Pediatric Nephrology, Diyarbakır Child's Hospital. A total of 54 pediatric patients (aged 6-17) diagnosed with renal scarring were included in the study. Dimercaptosuccinic acid renal scans were used for the diagnosis of renal scarring. Ambulatory Blood Pressure Monitoring was performed in all patients using a Spacelabs 90217. We also searched for urinary microalbuminuria. Results: HT was identified in 7 (13%) patients with renal scarring during the office measurements. On the other hand, 23 (42.7%) patients were found to have hypertension by Ambulatory Blood Pressure Monitoring. Patients showing severe and mild involvements on dimercaptosuccinic acid renal scans were compared in terms of frequency of hypertension and microalbuminuria ; however, no statistically significant difference was found. Conclusion: Renal scarring presents a risk for hypertension in children. Office blood pressure measurement is insufficient for hypertension detection in children with renal scarring; therefore, Ambulatory Blood Pressure Monitoring should be performed to establish accurate diagnosis.Keywords: Ambulatory blood pressure monitoring, children, hypertension, renal scar ÖZ Amaç: Skarlı böbrek olan çocuklarda hipertansiyon sıklığını saptamak. Yöntem: Bu çalışma, Şubat 2013 -Nisan 2015 tarihleri arasında Diyarbakır Çocuk Hastalıkları Hastanesi Çocuk Nefroloji Biriminde yürütülmüştür. Çalışmaya, renal skar tanısı konan toplam 54 çocuk hasta (yaşları 6-17) dahil edildi. Böbrek skarlanması tanısında Dimercaptosuccinic acid kullanıldı. Tüm hastalarda Spacelabs 90217 kullanılarak ayaktan kan basıncı izlemi uygulandı, ayrıca üriner mikroalbuminüri incelendi. Bulgular: Ofis ölçümleri sırasında renal skar bulunan 7 hastada (%13) hipertansiyon belirlendi. Öte yandan, ayaktan kan basıncı izlemi ile 23 (%42,7) sıklıkta hipertansiyon belirlendi. Dimercaptosuccinic acid renal incelemede şiddetli ve hafif tutulum gösteren hastalar, hipertansiyon ve mikroalbüminürisi sıklığı açısından karşılaştırıl-dı. Bununla birlikte, istatistiksel olarak anlamlı fark bulunamadı. Sonuç: Böbrek hasarlanması, çocuklarda hipertansiyon riski oluşturmaktadır. Renal hasarlı çocuklarda ofis kan basıncı ölçümü hipertansiyon belirlenmesi yetersizdir, bu nedenle doğru tanı koymak için ayaktan kan basıncı izlemi yapılmalıdır. Anahtar kelimeler:Yaşam içi kan basıncı izlemi, çocuklarda, hipertansiyon, renal skar

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“…Our previous study showed the rate of renal parenchymal scars after fi rst episode of acute pyelonephritis to be about 42% (1). The prevalence of renal scars in hypertensive children is 21% (2). Longitudinal studies estimate 3% to 30% increment of the occurrence of hypertension after longtime follow up of patients with a history of parenchymal scarring secondary to vesicoureteral refl ux (VUR) and UTI during childhood (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

The prevalence of hypertension and cardiovascular risks in children with renal scars secondary to urinary tract infection

Hooman

Isa-Tafreshi²,

Mostafavi³

et al. 2015

Paediatr Croat

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Dimercaptosuccinic acid (DMSA) renal scan in the evaluation of hypertension in children

Cited by 37 publications

References 20 publications

Primary versus secondary hypertension in children followed up at an outpatient tertiary unit

Primary versus secondary hypertension in children followed up at an outpatient tertiary unit

Frequency of Hypertension with Ambulatory Blood Pressure Monitoring in Children with Renal Damage

The prevalence of hypertension and cardiovascular risks in children with renal scars secondary to urinary tract infection

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