Dimeric naphthochromenes and other constituents from Sinningia allagophylla (Gesneriaceae)

Verdan, Maria Helena; Winiewski, Vanessa; Scharf, Dilamara Riva; Salvador, Marcos José; Sá, Eduardo L. de; Stefanello, Maria Élida Alves

doi:10.1016/j.phytol.2021.02.001

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…[8][9][10][11][12] The species of Gesneriaceae are traditionally used for respiratory problems, wounds, fever, inflammation, pain, snake bites, and infectious diseases. 10,12,13,14,15,16 Phytochemical research on Sinninigia species has mainly reported the identification of terpenes, phenolic glycosides, and compounds from the quinone class, some with documented biological activities such as antioxidant, anti-inflammatory properties, and cytotoxic activity for cancer cell lines. 10,12,14,15,16,17,18,19,20,21,22 Sinningia magnifica (Otto & A.…”

Section: Introductionmentioning

confidence: 99%

“…At least 75 species of herbs comprise the Sinningia genus, most of them native to Brazil 8‐12 . The species of Gesneriaceae are traditionally used for respiratory problems, wounds, fever, inflammation, pain, snake bites, and infectious diseases 10,12,13,14,15,16 …”

Section: Introductionmentioning

confidence: 99%

“…Phytochemical research on Sinninigia species has mainly reported the identification of terpenes, phenolic glycosides, and compounds from the quinone class, some with documented biological activities such as antioxidant, anti‐inflammatory properties, and cytotoxic activity for cancer cell lines 10,12,14,15,16,17,18,19,20,21,22 . Sinningia magnifica (Otto & A.…”

Section: Introductionmentioning

confidence: 99%

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Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Serain,

Buitrago‐Mejia,

de Souza

et al. 2023

Photochem & Photobiology

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Photodynamic therapy (PDT) has been used for various purposes, including as an antitumor resource in a noninvasive therapy with minimal side effects. Sinningia magnifica (Otto & A. Dietr.) Wiehler is a rupicolous plant found in rock crevices in Brazilian tropical forests. Initial studies indicate the presence of phenolic glycosides and anthraquinones in species of the genus Sinningia (Generiaceae family). It is known that anthraquinones are natural photosensitizers with potential PDT applications. This led us to investigate the potential compounds of S. magnifica for use as a natural photosensitizer against the melanoma (SK‐MEL‐103) and the prostate cancer (PC‐3) cell lines in a bioguided study. Our results showed that singlet oxygen production by the 1,3‐DPBF photodegradation assay greatly increased in the presence of crude extract and fractions. The biological activity evaluation showed photodynamic action against melanoma cell line SK‐MEL‐103 and prostate cell line PC‐3. These results suggest the presence of potential photosensitizing substances, as demonstrated in this in vitro antitumor PDT study by the naphthoquinones Dunniol and 7‐hydroxy‐6‐methoxy‐α‐dunnione for the first time. Naphthoquinones, anthraquinones and phenolic compounds were identified in the crude extract by UHPLC–MS/MS analysis, motivating us to continue with the bioguided phytochemical study aiming to discover more photochemically bioactive substances in Gesneriaceae plants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Serain,

Buitrago‐Mejia,

de Souza

et al. 2023

Photochem & Photobiology

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Quinones: Biosynthesis, Characterization of ¹³C Spectroscopical Data and Pharmacological Activities

Gomes de Carvalho,

Wellisson da Silva Mendes,

Martins da Costa

2023

Chemistry & Biodiversity

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Quinones are natural products widely distributed in nature, which are involved in stages of several vital biological processes, with mostly having a variety of pharmacological properties. The main groups comprising most of these compounds are benzoquinones, naphthoquinones, anthraquinones, and phenanthraquinones. Quinone isolation has been a focus of study around the world in recent years; for this reason, this study approaches the junction of natural quinones identified by 13C Nuclear Magnetic Resonance (NMR) spectroscopic analytical techniques. The methodology used to obtain the data collected articles from various databases on quinones from 2000 to 2022. As a result, 137 compounds were selected, among which 70 were characterized for the first time in the period investigated; moreover, the study also discusses the biosynthetic pathways of quinones and the pharmacological activities of the compounds found, giving an overview of the various applications of these compounds.

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Diversity of bacterial and fungal endophytic communities presents in the leaf blades of Sinningia magnifica, Sinningia schiffneri and Sinningia speciosa from different cladus of Gesneriaceae family: A comparative analysis in three consecutive years

Hernandez-Tasco

Tronchini

Apaza-Castillo

et al. 2023

Microbiological Research

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Dimeric naphthochromenes and other constituents from Sinningia allagophylla (Gesneriaceae)

Cited by 4 publications

References 9 publications

Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Quinones: Biosynthesis, Characterization of ¹³C Spectroscopical Data and Pharmacological Activities

Diversity of bacterial and fungal endophytic communities presents in the leaf blades of Sinningia magnifica, Sinningia schiffneri and Sinningia speciosa from different cladus of Gesneriaceae family: A comparative analysis in three consecutive years

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Dimeric naphthochromenes and other constituents from Sinningia allagophylla (Gesneriaceae)

Cited by 4 publications

References 9 publications

Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Quinones: Biosynthesis, Characterization of 13C Spectroscopical Data and Pharmacological Activities

Diversity of bacterial and fungal endophytic communities presents in the leaf blades of Sinningia magnifica, Sinningia schiffneri and Sinningia speciosa from different cladus of Gesneriaceae family: A comparative analysis in three consecutive years

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Quinones: Biosynthesis, Characterization of ¹³C Spectroscopical Data and Pharmacological Activities