Dimeric proanthocyanidins ofCotoneaster oligantha

Pashinina, L. T.; Chumbalov, T. K.; Шейченко, В. И.; Shukenova, R. Zh.

doi:10.1007/bf01134620

Cited by 5 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(-)-Epicatechin ( 24 ) and (+)-catechin ( 23 ), as markers of proanthocyanidin occurrence, have been detected in several Cotoneaster species, suggesting the presence of procyanidins in this genus. Although the available literature on this phenolic group is limited to a few reports [ 9 , 17 , 19 , 20 , 21 , 22 ] and requires more extensive research, it is known that B-type procyanidins are characteristic of the Cotoneaster species, mostly present in the form of di-, tri-, and tetramers of (-)-epicatechin, and that (-)-epicatechin ( 24 ), procyanidins B2 ( 26 ), and C1 ( 27 ) are the dominant components of the leaves and fruits.…”

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

“…The first phytochemical study of Cotoneaster plants can be traced back to 1974, when isoflavone compounds (biochanin A and its 7- O -glucoside) were isolated from the fruits and flowers of C. serotina and C. pannosa [ 8 ]. In a subsequent investigation on the leafy twigs of C. oligantha , (+)-catechin and (-)-epicatechin were isolated, as well as three isomeric B-type proanthocyanidins, with C4–C8 (or C4–C6) binding between flavan-3-ol monomers [ 9 ]. These studies initiated a number of further analyses leading to the isolation and identification of about 100 compounds, among which the flavonoids and proanthocyanidins are the most abundant phytochemicals in the genus Cotoneaster .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

View full text Add to dashboard Cite

Traditional herbal medicines have become a subject of global importance with both medical and economic implications. The regular consumption of herbal drugs has led to serious concerns regarding their quality, effectiveness, and safety. Thus, relevant scientific evidence has become an important criterion for the acceptance of traditional health claims. The genus Cotoneaster Medikus provides numerous species traditionally used in Asian medicine for the treatment of haemorrhoids, diabetes, and cardiovascular diseases. This review summarises the achievements of modern research on the Cotoneaster taxa, including ethnobotany, phytochemistry, pharmacology, and toxicology. To date, more than 90 compounds have been isolated or analytically identified in Cotoneaster leaves, fruits, flowers or twigs. These phytochemicals are categorised into flavonoids, procyanidins, phenolic acids, cotonefurans, cyanogenic glycosides, triterpenes, sterols, fatty acids, volatile compounds, and carbohydrates, and many of them are responsible for Cotoneaster pharmacological properties including antioxidant, anti-inflammatory, antimicrobial, antiparasitic, hepatoprotective, anti-diabetic or anti-dyslipidaemic activity. In order to ensure the safety of pharmaceutical applications, the potential toxicity of Cotoneaster extracts has also been investigated. In conclusion, this systematic review provides an important reference base for further study into the various medical applications of both the dry extracts and pure isolates of Cotoneaster species.

show abstract

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…As ornamental plants, few studies on the phytochemical properties and utilization of the genus Cotoneaster have been conducted. Some flavonoid constituents from C. wilsonii leaves were identified by Chang and Jeon [14] and Chumbalov et al [20]; many phenolic glycosides were isolated and identified from C. orbicularis by El-Mousallamy et al [21]; the flavonol and isoflavones from C. simonsii were studied and the flavonoid glycoside composition in C. thymaefolia was determined by Palme et al [19]; the proanthocyanidins in C. oligantha were identified by Pashinina et al [22]. C. multiflorus is an ornamental plant that is widely distributed in China, Korea, and Europe; it is a fruitbearing shrub with strong branches and deciduous leaves that is rich in nutrients and is a wild fruit tree resource that is still underexplored [23,24].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Extracts from Sarcocarp of Cotoneaster multiflorus

Liu

Jia

Jing

et al. 2018

Journal of Chemistry

View full text Add to dashboard Cite

The ethanol-water (7 : 3, v/v) extract of Cotoneaster multiflorus sarcocarp was sequentially fractionated by liquid-liquid partition using n-hexane, diethyl ether, methylene dichloride, and ethyl acetate. The contents of total polyphenols, total flavones, and oligomeric proanthocyanidins in the five parts (including the ethanol-water extract) were determined. In addition, 2,2-diphenyl-1-picrylhydrazyl free radical-scavenging, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation decolorization, reducing power, ferric reducing antioxidant power, and lipid peroxidation inhibition assays were conducted to test the antioxidant activities of Sample 1 (the ethanol-water fraction) and Sample 2 (the ethyl acetate fraction) in vitro. In the above five assays, Sample 2 showed greater antioxidant capacities than Sample 1. Furthermore, Sample 2 was better able to protect low-density lipoproteins from oxidation in a dose-dependent manner. The test results show that C. multiflorus sarcocarp, especially the ethyl acetate-soluble fraction, may be a potential source of natural antioxidants.

show abstract

“…In different in vitro tests, they are reported to have antibacterial, anti-plasmodial, anti-cholinesterase, anti-tyrosinase, antioxidant, anti-dyslipidemic, anti-glucosidase, anti-amylase, anti-diabetic, hepatoprotective and cytotoxic activities [13,15,16,17,18]. Most of these bioactivities can be attributed to the presence of low-molecular weight polyphenols including simple phenolic acids, flavonoids [19,20,21,22,23], dibenzofuran derivatives [24,25], and dimeric proanthocyanidins [26]. Metabolites of this type were isolated from twigs, leaves or roots of several species known for their ethnopharmacological significance such as C. orbicularis Schlecht.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species

et al. 2016

View full text Add to dashboard Cite

Abstract:The antioxidant efficiency of 70% aqueous methanolic extracts from the leaves of twelve selected Cotoneaster Medik. species was evaluated using four complementary in vitro tests based on SET-(single electron transfer) and HAT-type (hydrogen atom transfer) mechanisms (DPPH, FRAP, O 2 ‚´a nd H 2 O 2 scavenging assays). The samples exhibited the dose-dependent responses in all assays with activity parameters of EC 50 = 18.5-34.5 µg/mL for DPPH; 0.9-3.8 mmol Fe 2+ /g for FRAP; SC 50 = 27.7-74.8 µg/mL for O 2 ‚´; and SC 50 = 29.0-91.3 µg/mL for H 2 O 2 . Significant linear correlations (|r| = 0.76-0.97, p < 0.01) between activity parameters and total contents of phenolics (5.2%-15.4% GAE) and proanthocyanidins (2.1%-15.0% CYE), with weak or no effects for chlorogenic acid isomers (0.69%-2.93%) and total flavonoids (0.28%-1.40%) suggested that among the listed polyphenols, proanthocyanidins are the most important determinants of the tested activity. UHPLC-PDA-ESI-QTOF-MS analyses led to detection of 34 polyphenols, of which 10 B-type procyanidins, 5 caffeoylquinic acids and 14 flavonoids were identified. After cluster analysis of the data matrix, the leaves of Cotoneaster zabelii, C. splendens, C. bullatus, C. divaricatus, C. hjelmqvistii and C. lucidus were selected as the most promising sources of natural antioxidants, exhibiting the highest phenolic levels and antioxidant capacities, and therefore the greatest potential for pharmaceutical applications.

show abstract

Dimeric proanthocyanidins ofCotoneaster oligantha

Cited by 5 publications

References 4 publications

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Antioxidant Activities of Extracts from Sarcocarp of Cotoneaster multiflorus

Phenolic Profile and Antioxidant Potential of Leaves from Selected Cotoneaster Medik. Species

Contact Info

Product

Resources

About