Dimeric rhenium(IV) and monomeric rhenium(I) and (V) complexes of orotic acid

International audienceSynthetic pathways to a range of potentially N3O-tetradentate ligands designed to coordinate to rhenium cores, as well as their coordination behaviors towards different rhenium cores (oxidation states +I and +V) are investigated. Two functionalized N-{[1-(4-R)-1H-1,2,3-triazol-4-yl]methyl}-2-(pyridin-2-ylmethoxy)aniline derivatives L1H (R = methyl acetate) and L2H (R = 4-nitrophenyl) act exclusively as bidentate ligands and lead to the formation of mononuclear tricarbonylrhenium(I) complexes of the general formula [(LH)Re(CO)3Cl] with L = L1 or L2. Both complexes are characterized by 1H NMR and 13C NMR, FTIR spectroscopy, electrospray ionization mass spectrometry, and in the case of [(L2H)Re(CO)3Cl], single-crystal X-ray diffraction. The rhenium is coordinated by three carbonyl groups, a chlorine atom and two nitrogen atoms of a triazole group, and a nitrogen of the aniline ring of the ligand, respectively. A theoretical study shows complex [(L2H)Re(CO)3Cl] is the most stable structural isomer. In addition, the oxorhenium(V) complex [(L3)ReO] is isolated and fully characterized after the reaction of the ReV precursor [ReOCl3(PPh3)2] with L3H3 [methyl 2-(4-{[2-(2-hydroxyphenylamino)-2-oxoethylamino]methyl}-1H-1,2,3-triazol-1-yl)acetate]. Its corresponding 99mTc complex was achieved with a good radiochemical yield (andgt; 90 %). The convenient synthesis of this ligand, coupled with its high affinity for [ReO]3+ and [99mTcO]3+ cores, make it a promising chelator for biomedical applications. © 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinhei

show abstract

Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

Wang

Eychenne

Wolff

et al. 2017

Eur J Inorg Chem

View full text Add to dashboard Cite

show abstract

Complexes of orotic acid and derivatives with the fac-[M(CO)3]+ (M = Re and 99Tc/99mTc) core as radiopharmaceutical probes

Mukiza

Braband

Bolliger

et al. 2022

Inorganica Chimica Acta

View full text Add to dashboard Cite

2-Mercapto-orotic acid as a bridging chelate in a Re(III)Re(IV) dimer with a metal-metal bond

Mukiza

Gerber

Hosten

2016

Inorganic Chemistry Communications

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dimeric rhenium(IV) and monomeric rhenium(I) and (V) complexes of orotic acid

Cited by 9 publications

References 38 publications

Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

Design, Synthesis, and Reactivity of Multidentate Ligands with Rhenium(I) and Rhenium(V) Cores

Complexes of orotic acid and derivatives with the fac-[M(CO)3]+ (M = Re and 99Tc/99mTc) core as radiopharmaceutical probes

2-Mercapto-orotic acid as a bridging chelate in a Re(III)Re(IV) dimer with a metal-metal bond

Contact Info

Product

Resources

About