Dimerumic acid and deferricoprogen produced by Monascus purpureus attenuate liquid ethanol diet-induced alcoholic hepatitis via suppressing NF-κB inflammation signalling pathways and stimulation of AMPK-mediated lipid metabolism

Lai, Jhao-Ru; Ke, Bo-Jun; Hsu, Ya-Wen; Lee, Chun-Lin

doi:10.1016/j.jff.2019.05.049

Cited by 4 publications

(1 citation statement)

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“…Pigments and monacolin K production are influenced by the strain of Monascus fungi, the fermentation substrate, and the conditions during fermentation (Miyake et al 2008 ; Feng et al 2012 ; Chen et al 2019 ; Kraboun et al 2019 ). Moreover, Monascus fungi produce additional bioactive compounds, such as dimerumic acid, deffericoprogen, and γ-aminobutyric acid (GABA) which can improve the bioactivities of the substrates (Lai et al 2019 ; Su et al 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Utilization of agro-industrial by-products in Monascus fermentation: a review

Srianta

Kusdiyantini

Zubaidah

et al. 2021

Bioresour. Bioprocess.

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The Monascus fermentation industry has gained global attention. Its key products, i.e., pigments, functional food ingredients, food supplements, and medicinal use, are growing in the world’s market. Efforts to find the cost-effective substrate for Monascus fermentation have remained the target. This paper aimed to appraise the utilization of agro-industrial by-products (cereal, starchy tuber and root, legume, fruit, and coffee processing) as a cost-effective substrate for Monascus fermentation. The specific objective was to review the by-products pre-treatment, the fermentation process, product yield, and the bioactivity of the fermented products. Among all the by-products that could be used as the fermentation substrate, cereal brans do not need pre-treatment, but others need a suitable pre-treatment step, e.g., cassava peel, okara, and jackfruit seed to list a few, that need to be powdered beforehand. Other substrates, such as corn cob and durian seed, need soaking and size reduction through the pre-treatment step. During fermentation, Monascus produce many pigments, monacolin K, associated with rise in phenolic and flavonoid contents. These products possess antioxidant, antihypercholesterol, antidiabetes, and antiatherosclerosis activities which underpin their health significance. In conclusion, we report in this review the agro-industrial by-products which have potential prospects for pigments, functional food ingredients, food supplements, and therapeutic usages produced from Monascus fermentation.

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Section: Introductionmentioning

confidence: 99%

Utilization of agro-industrial by-products in Monascus fermentation: a review

Srianta

Kusdiyantini

Zubaidah

et al. 2021

Bioresour. Bioprocess.

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Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications

Stefaniak,

Nowak,

Skwarecki

2024

CMC

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Siderophores are low molecular weight compounds produced by microorganisms to scavenge iron in iron-deficient environments. Rhodotorulic acid, a natural hydroxamate siderophore, plays a vital role in iron acquisition for fungi and bacteria. As the simplest natural hydroxamate siderophore, it exhibits a high affinity for ferric ions, enabling it to form stable complexes that facilitate iron uptake and transport within microorganisms. This article provides a comprehensive analysis of this hydroxamate siderophore, rhodotorulic acid, its synthesis, physicochemical properties, and biological significance. It also explores its applications in antifungal and plant protection strategies. Insights into RA derivatives reveal distinct biological effects and applications with potential in various fields, from antioxidants to antifungals. Rhodotorulic acid and its derivatives show promise for novel therapies, plant protection strategies, and iron supplementation in agriculture. Understanding their properties could advance science and medicine with sustainable practices.

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Comparative Effects of Monascin and Monascinol Produced by Monascus pilosus SWM-008 on Pro-Inflammatory Factors and Histopathological Alterations in Liver and Kidney Tissues in a Streptozotocin–Nicotinamide-Induced Rat Model

Yang,

Hsu,

Pan

et al. 2024

JoF

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Monascinol (Msol), an analog of monascin (MS) produced by Monascus pilosus, possesses potential anti-inflammatory properties. This study compares the effects of M. pilosus SWM-008 fermented red mold rice, which contains the functional components MS and Msol, on liver and kidney damage related to diabetic complications in rats. An animal model of liver and kidney injury was induced by an intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg body weight combined with nicotinamide (NA) at 150 mg/kg body weight. Our findings indicate that Msol significantly reduces STZ-NA induced pro-inflammatory markers, including interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2 (COX-2) in both liver and kidney tissues. Significant improvements were noted in the histopathological assessments. Msol was more effective than MS in suppressing renal IL-1β and COX-2 expressions. In summary, the findings indicate that Msol shows potential as a novel therapeutic agent for treating liver and kidney injuries associated with diabetic complications.

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Dimerumic acid and deferricoprogen produced by Monascus purpureus attenuate liquid ethanol diet-induced alcoholic hepatitis via suppressing NF-κB inflammation signalling pathways and stimulation of AMPK-mediated lipid metabolism

Cited by 4 publications

References 50 publications

Utilization of agro-industrial by-products in Monascus fermentation: a review

Utilization of agro-industrial by-products in Monascus fermentation: a review

Rhodotorulic Acid and its Derivatives: Synthesis, Properties, and Applications

Comparative Effects of Monascin and Monascinol Produced by Monascus pilosus SWM-008 on Pro-Inflammatory Factors and Histopathological Alterations in Liver and Kidney Tissues in a Streptozotocin–Nicotinamide-Induced Rat Model

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