Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line

Li, Qing; Nakadai, Ari; Ishizaki, Masamichi; Morimoto, Kanehisa; Ueda, Atsushi; Krensky, Alan M.; Kawada, Tomoyuki

doi:10.1016/j.tox.2005.05.018

Cited by 36 publications

(29 citation statements)

References 23 publications

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“…Phytoncides released from trees as well as decreased production of stress hormones may also partially contribute to this increased NK activity (Li, 2010a;. Because NK cells can kill tumor cells by releasing anti-cancer proteins such as perforin, GRN, and GrA/B (Okada et al, 2003;Li et al, 2004Li et al, , 2005b and forest visits increase NK activity and intracellular levels of anticancer proteins, we can conclude that forest visits may have a preventive effect on cancer cell generation and development.…”

Section: Mechanism Of Increase In Nk Activitymentioning

confidence: 99%

“…It has been reported that NK cells kill tumor or virus-infected cells by releasing perforin, granzymes, and GRN via the granule exocytosis pathway (Okada et al, 2003;Li et al, 2004Li et al, , 2005b. To explore the mechanism of enhancement of NK activity, the effect of being in the forest environment on intracellular levels of perforin, GRN, and GrA/B in PBL was investigated.…”

Section: Effect Of Forest Environments On Nk Activity In Male Subjectsmentioning

confidence: 99%

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Nature Therapy and Preventive Medicine

Lee¹,

Li²,

Tyrväinen³

et al. 2012

Public Health - Social and Behavioral Health

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Section: Mechanism Of Increase In Nk Activitymentioning

confidence: 99%

Section: Effect Of Forest Environments On Nk Activity In Male Subjectsmentioning

confidence: 99%

Nature Therapy and Preventive Medicine

Lee¹,

Li²,

Tyrväinen³

et al. 2012

Public Health - Social and Behavioral Health

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“…NK cells have been reported to kill tumors or virus-infected cells through the release of perforin, granzymes, and GRN via the granule exocytosis pathway [8][9][10][11][12]. Li et al [1] incubated NK-92MI cells, an interleukin-2-independent human NK cell line, in the presence of phytoncides, such as a-pinene, 1,8-cineole, d-limonene, and essential oils extracted from trees including Japanese cedar (Cryptomeria, Sugi in Japanese) and Chamaecyparis obtuse (Hinoki in Japanese), for 48-144 h and then measured NK activity and the intracellular levels of perforin, GrA, and GRN [1].…”

Section: Effect Of Phytoncides (Essential Oils) From Trees On Human Imentioning

confidence: 99%

“…1b). It has been reported that NK cells kill tumor or virus-infected cells through the release of perforin, granzymes, and GRN via the granule exocytosis pathway [8][9][10][11][12]. In order to explore the mechanism of enhancement of NK activity induced by forest bathing, the effect of forest bathing on the intracellular levels of perforin, GRN, and GrA/B in PBL was investigated.…”

Section: Effect Of Forest Bathing Trips On Human Immune Functionmentioning

confidence: 99%

Effect of forest bathing trips on human immune function

2009

Environ Health Prev Med

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In Japan, a forest bathing trip, called "Shinrinyoku" in Japanese, is a short, leisurely visit to a forest; it is regarded as being similar to natural aromatherapy. This review focuses on the effects of forest bathing trips on human immune function. Beginning in 2005, adult Japanese individuals, both male and female, participated in a series of studies aimed at investigating the effect of forest bathing trips on human immune function. The subjects experienced a 3-day/2-night trip to forest areas, and blood and urine were sampled on days 2 (the first sampling during each trip) and 3 (the second sampling during each trip), and on days 7 and 30 after the trips. Natural killer (NK) activity, the numbers of NK, granulysin-, perforin-, and granzymes A/B-expressing lymphocytes in the blood, and the concentration of urinary adrenaline were measured. The same measurements were made before the trips on a normal working day as a control. The mean values of NK activity and the numbers of NK, granulysin-, perforin-, and granzymes A/B-expressing cells on forest bathing days were significantly higher than those on the control days, whereas the mean values of the concentration of urinary adrenaline on forest bathing days were significantly lower than that on the control days in both male and female subjects. The increased NK activity lasted for more than 30 days after the trip, suggesting that a forest bathing trip once a month would enable individuals to maintain a higher level of NK activity. In contrast, a visit to the city as a tourist did not increase NK activity, the numbers of NK cells, or the level of intracellular granulysin, perforin, and granzymes A/B. These findings indicate that forest bathing trips resulted in an increase in NK activity, which was mediated by increases in the number of NK cells and the levels of intracellular granulysin, perforin, and granzymes A/B.

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“…It has been reported that OP pesticides show immunotoxicity in human and animals both in vivo (Li et al, 2004) and in vitro (Li, 2007;Li et al, 2000Li et al, , 2002Li et al, , 2005Li et al, , 2008. Several investigators have tried to elucidate the mechanism of OP-induced immunotoxicity from the aspect of apoptosis (Li et al, , 2009Nakadai et al, 2006;Olgun et al, 2004;Saleh et al, 2003aSaleh et al, , 2003b.…”

Section: Op Pesticides Induce Apoptosis In Immune Cells In Vitromentioning

confidence: 99%

Apoptosis Induced by Anticholinesterase Pesticides

2011

Anticholinesterase Pesticides

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Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line

Cited by 36 publications

References 23 publications

Nature Therapy and Preventive Medicine

Nature Therapy and Preventive Medicine

Effect of forest bathing trips on human immune function

Apoptosis Induced by Anticholinesterase Pesticides

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