Dimethyl Ether of D-Tubocurarine Iodide as a Curarizing Agent in Anaesthesia for Thoracic Surgery

Wilson, Howard Bruce; Gordon, Helen E.; Raffan, A. W.

doi:10.1136/bmj.1.4665.1296

Cited by 11 publications

(2 citation statements)

References 2 publications

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“…It may be seen from table I that dimethyltubocurarine 9.17 mg was needed per m 2 during 90 min, while tubocurarine 18.3 mg was needed under similar conditions (Stovner, Theodorsen and Bjelke, 1971a). This makes dimethyltubocurarine twice as potent as tubocurarine, a finding which is in good agreement with that of Wilson, Gordon and Raffan (1950). It is interesting that methyl substitution in tubocurarine has resulted in a compound with higher blocking activity, while in the case of toxiferine Waser (1962) showed that the compound with two free hydroxyl groups had the highest action.…”

Section: General Properties Of the Relaxantssupporting

confidence: 71%

Sensitivity to Dimethyltubocurarine and Toxiferine With Special Reference to Serum Proteins

Stovner

Theodorsen

Bjelke

1972

British Journal of Anaesthesia

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Section: General Properties Of the Relaxantssupporting

confidence: 71%

Sensitivity to Dimethyltubocurarine and Toxiferine With Special Reference to Serum Proteins

Stovner

Theodorsen

Bjelke

1972

British Journal of Anaesthesia

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“…Although metocurine has been available since its synthesis by King in 1935, it has not been popular in clinical use despite early studies suggesting less histamine release (Wilson, Gordon and Raffan, 1950) and little effect on arterial pressure (Stoelting, Graf and Vieira, 1948). More recent studies have confirmed the absence of significant autonomic effects both in animals (Hughes and Chappie, 1976a;Savarese, 1979) and man (Savarese, Ali and Antonio, 1977;Zaiden et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Comparative Haemodynamic Effects of Tubocurarine and Metocurine in the Dog

Antonio

Philbin

Savarese

1979

British Journal of Anaesthesia

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On accout of its histamine releasing and ganglion blocking properties tubocurarine is known to have significant haemodynamic effects. Methylation of the compound produces metocurine and should decrease both histamine release and ganglionic blockade. The haemodynamic effects of these two compounds were compared in 10 mongrel dogs anaesthetized with chloralose and morphine. Haemodynamic measurements were made 2 min before and 2, 5, 10 and 20 min after administration of the drugs. Each animal received three doses of each drug with a 2-h rest period between doses: tubocurarine 0.35 (muscle twitch ED95), 0.7 and 1.4 mg kg-1 and metocurine 0.2 (2 x ED95), 0.4 and 0.8 mg kg-1. All doses of tubocurarine produced an increase in heart rate (212, 197 and 212% of control respectively). The mean arterial pressure decreased significantly with 0.7 mg kg-1 (48% of control; P less than 0.05). Metocurine produced no significant haemodynamic effects except for the largest dose (8 x ED95). The data suggest that the haemodynamic margin of safety with metocurine in the dog is eight times that of tubocurarine.

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Intubationsnarkose und Curareanwendung in der modernen Anästhesie

Schmitt

1952

Ergebnisse Der Chirurgie Und Orthopädie

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Dimethyl Ether of D-Tubocurarine Iodide as a Curarizing Agent in Anaesthesia for Thoracic Surgery

Cited by 11 publications

References 2 publications

Sensitivity to Dimethyltubocurarine and Toxiferine With Special Reference to Serum Proteins

Sensitivity to Dimethyltubocurarine and Toxiferine With Special Reference to Serum Proteins

Comparative Haemodynamic Effects of Tubocurarine and Metocurine in the Dog

Intubationsnarkose und Curareanwendung in der modernen Anästhesie

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