Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional 1H and two‐dimensional 1H‐13C NMR

Engelke, Udo F. H.; Tangerman, A.; Willemsen, M.A.A.P.; Moskau, Detlef; Loss, Sandra; Mudd, S. Harvey; Wevers, Ron A.

doi:10.1002/nbm.966

Cited by 85 publications

(88 citation statements)

References 22 publications

(22 reference statements)

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“…Two separate studies performed by Cottler-Fox and coworkers [239] and Wever and co-workers [240] found that Me 2 SO 2 was present in human plasma and cerebrospinal fluid ranging from 0 to 25 lM. Me 2 SO 2 was also detected by magnetic resonance spectroscopy in the brains of patients with memory loss and in normal patients given doses of 1-3 g/day [241].…”

Section: Antioxidant and Pro-oxidant Effects Of Oxo-sulfur Compounds mentioning

confidence: 94%

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Ramoutar

Brumaghim

2010

Cell Biochem Biophys

102

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Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This review discusses the ability of inorganic selenium compounds, such as selenite, and selenate, to prevent damage from reactive oxygen species as well as their ability to promote cell death by reactive oxygen species generation. Oxo-sulfur and selenium compounds, such as allicin, dimethyl sulfone, methionine sulfoxide, and methylselenenic acid also have similar abilities to act as both antioxidants and pro-oxidants, but the mechanisms for these behaviors are distinctly different from those of the inorganic selenium compounds. The antioxidant and pro-oxidant properties of these small-molecule sulfur and selenium compounds are extremely complex and often greatly depend on experimental conditions, which may explain contradictory literature reports of their efficacy.

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Section: Antioxidant and Pro-oxidant Effects Of Oxo-sulfur Compounds mentioning

confidence: 94%

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Ramoutar

Brumaghim

2010

Cell Biochem Biophys

102

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“…Plasma samples were prepared for 1 H NMR spectroscopy with minimal handling as described [12]. For statistical analyses of the whole metabolic profile, spectra were data reduced in numerical format by integrating spectral regions (buckets) every 0.02 ppm (parts per million) and scaled to the total intensity of the spectrum with Amix 3.6.8 software (Bruker Analytische Messtechnik, Germany) from 0.8 to 8.6 ppm; the water peak area was excluded from each spectrum (4.4 to 5.2 ppm).…”

Section: Methodsmentioning

confidence: 99%

Early Energy Deficit in Huntington Disease: Identification of a Plasma Biomarker Traceable during Disease Progression

et al. 2007

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Huntington disease (HD) is a fatal neurodegenerative disorder, with no effective treatment. The pathogenic mechanisms underlying HD have not been elucidated, but weight loss, associated with chorea and cognitive decline, is a characteristic feature of the disease that is accessible to investigation. We, therefore, performed a multiparametric study exploring body weight and the mechanisms of its loss in 32 presymptomatic carriers and HD patients in the early stages of the disease, compared to 21 controls. We combined this study with a multivariate statistical analysis of plasma components quantified by proton nuclear magnetic resonance (1H NMR) spectroscopy. We report evidence of an early hypermetabolic state in HD. Weight loss was observed in the HD group even in presymptomatic carriers, although their caloric intake was higher than that of controls. Inflammatory processes and primary hormonal dysfunction were excluded. 1H NMR spectroscopy on plasma did, however, distinguish HD patients at different stages of the disease and presymptomatic carriers from controls. This distinction was attributable to low levels of the branched chain amino acids (BCAA), valine, leucine and isoleucine. BCAA levels were correlated with weight loss and, importantly, with disease progression and abnormal triplet repeat expansion size in the HD1 gene. Levels of IGF1, which is regulated by BCAA, were also significantly lower in the HD group. Therefore, early weight loss in HD is associated with a systemic metabolic defect, and BCAA levels may be used as a biomarker, indicative of disease onset and early progression. The decreased plasma levels of BCAA may correspond to a critical need for Krebs cycle energy substrates in the brain that increased metabolism in the periphery is trying to provide.

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“…The four remaining metabolites, citric acid, creatine, dimethylsulfone and fructose, all display elevated levels in PD patients when compared to controls. Dimethylsulfone is involved in the methanethiol pathway, in which it is produced as a breakdown product of the nitric oxide synthase cofactor methanethiol (Engelke et al 2005). Fructose is linked to the mannose and fructose pathway, and citric acid to numerous metabolic pathways; future studies of larger patient cohorts will clarify their importance.…”

Section: Pd Patients Compared To Control Subjectsmentioning

confidence: 99%

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

Wuolikainen

Trupp

et al. 2016

Metabolomics

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Introduction Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are two severe neurodegenerative disorders for which the disease mechanisms are poorly understood and reliable biomarkers are absent. Objectives To identify metabolite biomarkers for ALS and PD, and to gain insights into which metabolic pathways are involved in disease. Methods Nuclear magnetic resonance (NMR) metabolomics was utilized to characterize the metabolite profiles of cerebrospinal fluid (CSF) and plasma from individuals in three age, gender, and sampling-date matched groups, comprising 22 ALS, 22 PD and 28 control subjects. Results Multivariate analysis of NMR data generated robust discriminatory models for separation of ALS from control subjects. ALS patients showed increased concentrations of several metabolites in both CSF and plasma, these are alanine (CSF fold change = 1.22, p = 0.005), creatine (CSF-fc = 1.17, p = 0.001), glucose (CSFfc = 1.11, p = 0.036), isoleucine (CSF-fc = 1.24, p = 0.002), and valine (CSF-fc = 1.17, p = 0.014). Additional metabolites in CSF (creatinine, dimethylamine and lactic acid) and plasma (acetic acid, glutamic acid, histidine, leucine, pyruvate and tyrosine) were also important for this discrimination. Similarly, panels of CSFmetabolites that discriminate PD from ALS and control subjects were identified. Conclusions The results for the ALS patients suggest an affected creatine/creatinine pathway and an altered branched chain amino acid (BCAA) metabolism, and suggest links to glucose and energy metabolism. Putative metabolic markers specific for ALS (e.g. creatinine and lactic acid) and PD (e.g. 3-hydroxyisovaleric acid and mannose) were identified, while several (e.g. creatine and BCAAs) were shared between ALS and PD, suggesting some overlap in metabolic alterations in these disorders. Keywords Amyotrophic lateral sclerosis (ALS) Á Parkinson's disease (PD) Á NMR metabolomics Á Biomarker Á Cerebrospinal fluid (CSF) Á Plasma Abbreviations ALS Amyotrophic lateral sclerosis PD Parkinson's disease NMR Nuclear magnetic resonance MS Mass spectrometry EDTA Ethylenediaminetetraacetic acid CSF Cerebrospinal fluid CPMG Carr-Purcell-Meiboom-Gill PCA Principal component analysis OPLS Orthogonal projection to latent structures DA Discriminant analysis EP Effect projection CV-ANOVA Analysis of variance testing of crossvalidated predictive residuals CNS Central nervous system BCAA Branched chain amino acids Electronic supplementary material The online version of this article (

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Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one‐dimensional ¹H and two‐dimensional ¹H‐¹³C NMR

Cited by 85 publications

References 22 publications

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Early Energy Deficit in Huntington Disease: Identification of a Plasma Biomarker Traceable during Disease Progression

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

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